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Marker genes commonly used to detect circulating cancer cells are expressed in activated lymphocytes

100%

Kowalewska M., Chechlinska M., Sergiusz M., Kober P., Nowak R.

Acta Biochimica Polonica

2006

tom 53

nr Supplement 1

Sera of lung cancer patients affect the release of TH1, TH2 and monocyte-derived cytokines, and the expression of IL-2Ralpha by normal, stimulated mononuclear cells

100%

Chechlinska M., Duma A., Swierkowska A., Kaminska J., Steffen J.

Cellular and Molecular Biology Letters

2004

tom 09

nr 1

We have shown that the sera of lung cancer patients affect the response of ConA-stimulated normal peripheral blood mononuclear cells by decreasing the expression of IL-2Rα and inhibiting the release of IL-1β and IL-2. A tendency to enhance the release of IL-6 was also observed. We conclude that an imbalance in the Th1/Th2 cytokine response, typical for cancer patients, may at least partly be related to soluble factors circulating in the patients’ blood. We discuss a putative role of serum IL-10, IL-1ra, and soluble IL-2Rα in the effects observed.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Cellular and Molecular Biology Letters

2 Chechlinska M.

1 Duma A.

1 Kaminska J.

1 Kober P.

1 Kowalewska M.

1 Nowak R.

1 Sergiusz M.

1 Steffen J.

1 Swierkowska A.

1 2006

1 2004

Wyniki wyszukiwania

Marker genes commonly used to detect circulating cancer cells are expressed in activated lymphocytes

Sera of lung cancer patients affect the release of TH1, TH2 and monocyte-derived cytokines, and the expression of IL-2Ralpha by normal, stimulated mononuclear cells