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The objectives of the studies was to evaluate a the­rapeutic efficacy of enrofloxacin in salmonellosis of pigs in field conditions. The experiments were performed on 425 weaners with clinical symptoms of salmonellosis treated with Baytril at a dose of 2.5 mg/kg bw for 5 days. The efficacy of Baytril was compared with that of chloramphenicol which up to now gave the best effects in a chosen farm. Chloramphenicol was used in 185 sick pigs at a dose of 5.0 mg/kg bw for 5 days. The efficacy of Baytril was evaluated on the basis of time of diarrhoea persistance, percentage of cured and died treated weaners. The antibiotic sensitivity tests of S. choleraesuis to enro­floxacin were also included. It was found that out of 425 treated weaners with Baytril only 3.8% of pigs died; in controls (animals treated with chloramphenicol) 13.5% of weaner died. Seventy five percent of S. choleraesuis isolates were highly sensitive and 25% of isolated were mildly sensitive to enrofloxacin. Besides neomycin more than 50% of the isolates were resistant or slightly sensitive to other antibiotics studied.
This review of the literature is characterising the aetiology of the diarrhoea of suckling piglets with reference to pathogenic bacteria and viruses,also including the influence of the unfavourable environmental factors. The laboratory investigations of faecal samples demonstrated the etiological importance of E.coli, not only those with haemolytic properties but also non haemolytic strains. The majority of E.coli strains of etiological importance belonged to pathotype EPEC. These strains produced one or several enterotoxins, being thermostable or termolable.They produce fimbrial antigens: F4, F5, F6 and F41. Strains of Clostridium perfringens cultured from the majority of feaces samples belong to type A. The Rotavirus type A, in comparison with TGEV and PEDV plaid the leading role in the multifactorial aetiology of suckling piglet diarrhoea. Concluding, exact definition of aetiology of piglet diarrhoea is at present not possible and requires further research. These results could eventually more precisely define, than it is possible at present, the passive prophylaxis of the diarrhoea of suckling piglets and a more adequate choice of drugs.
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