Municipal and industrial effluents discharged into the River Delimi at midstream seriously affect the environment with enhanced levels of some chemical variables. Species richness, diversity, and biotic scores of macroinvertebrates were lowest at the affected zone for all taxa, while density and biomass were higher only for pollution-tolerant species of Mollusca, Oligochaeta, and Diptera. Unaffected and recovery zones were heterotrophic (P/R < 1), while the affected zone was autotrophic (P/R > 1) owing to dense algal mats. The results indicate a strong anthropogenic effect leading to habitat degradation.