Wyniki wyszukiwania

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Exploration of new environment revealas extensive deprivation-induced plasticity

100%

Radwanska A., Filipkowski R., Zakrzewska R., Kossut M.

Acta Neurobiologiae Experimentalis

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2009

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tom 69

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nr 3

Sensory deprivation elicits alterations in the functional organization of the primary somatosensory cortex. It was shown that plucking out all but one row of whiskers in adult mice evokes broadening of the functional representation of the spared row, as measured with radioactive 2-deoxyglucose (2-DG) uptake during passive stimulation of whiskers. We would like to establish whether changes in metabolic activity caused by sensory deprivation are paralleled by changes at genomic levels visualized by immediate early genes immunohistochemistry Exploration of enriched environment is a powerful trigger to induce immediate early genes in the barrel cortex. In this study we show that plasticity of the functional representation of the spared row of whiskers can be estimated by radioactive 2-DG method in animals actively using their whiskers while exploring new environment. Expansion of the spared row representation in the deprived hemisphere reaches 140% of the control (non-deprived) hemisphere after 1 week of deprivation and spreads to whole barrel fi eld after four weeks of deprivation. We also show that induction of some early immediate genes during exploration of new environment is limited to the non-deprived barrels after one day of deprivation. In further course of studies we will perform immunohistochemical reactions for proteins encoded by early immediate genes in brains from animals deprived for 1 or 4 weeks.

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Thermophysical and chemical properties of perennial energy crops depending on harvest period

76%

Stolarski M. J., Krzyzaniak M., Snieg M., Slominska E., Piorkowski M., Filipkowski R.

International Agrophysics

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2014

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tom 28

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nr 2

This paper presents analyses of the thermophysical and chemical properties of eleven perennial crop species harvested in one-year rotation cycles. The crops included four species grown for biomass in the form of straw, five species producing semi-wood biomass, and two species yielding wood biomass. The research comprised three consecutive crop harvests. In each harvesting season, biomass samples for analyses were taken on six dates at one-month intervals. Thermophysical and chemical properties of the biomass were significantly differentiated within the main experimental factors and their interactions. The biomass produced by Virginia mallow had the best quality parameters as solid fuel. In fact, it achieved the lowest water content and the highest lower heating value during all of the analyzed seasons and harvest dates. The biomass of the species yielding straw or semi-wood products attained better quality as solid fuel on later harvest dates. In turn, the quality of willow biomass remained practically unchanged between the harvest dates.

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New hippocampal neurons are not obligatory for memory formation:mice with no adult brain neurogenesis show learning

51%

Jaholkowski P., Kiryk A., Jedynak P., Ben Abdallah N., Knapska E., Kowalczyk A., Piechal A., Blacharz-Klin K., Widy-Tyszkiewicz E., Wilczynski G., Lipp H., Kaczmarek L., Filipkowski R.

Acta Neurobiologiae Experimentalis

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2009

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tom 69

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nr 3

New neurons are produced in the brains of adult animals, including humans, throughout the lifespan. Since one of the site of adult brain neurogenesis is the hippocampal formation, a brain structure involved in learning and memory, new neurons were expected to be involved in these phenomena. However, the very evidence supporting this hypothesis remains limited, inconsistent and in most cases indirect. Also, the experiments in which adult neurogenesis is blocked use irradiation and drugs known for their side effects. We used a novel approach, cyclin D2 knock-out mice (D2 KO mice), specifi cally lacking adult brain neurogenesis (which was verifi ed using DCX and NeuN staining) to verify its importance in learning and memory. D2 KO mice and their wild type siblings were tested in several behavioral paradigms including those in which the role of adult neurogenesis has been postulated. D2 KO mice showed no impairment in sensorimotor tests with only sensory impairment in an olfaction-dependent task. However, D2 KO mice showed proper procedural learning as well as learning in context (including remote memory), cue and trace fear-conditioning, Morris water maze, novel object recognition test, and in a multifunctional behavioral system – Intellicages. Our results suggest that adult brain neurogenesis is not obligatory in learning, including the kinds of learning where the role of adult neurogenesis has previously been strongly suggested. Support – MNiSW grant no N303 051 31/1624.

4

Udzial regulacji ekspresji genow w procesach integracji informacji w komorkach nerwowych.

45%

Kaczmarek L., Kaminska-Kaczmarek B., Savonenko A., Lukasiuk K., Jaworski J., Biedermann I., Zielinski K., Werka T., Nikolaev E., Szklarczyk A., Dzwonek J., Kowalczyk A., Konopka D., Nowicka D., Rydz M., Filipkowski R., Figiel-Ozog I.

Działalność Naukowa PAN. Wybrane Zagadnienia

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2000

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tom 09

46-48

Ograniczanie wyników

Exploration of new environment revealas extensive deprivation-induced plasticity

Thermophysical and chemical properties of perennial energy crops depending on harvest period

New hippocampal neurons are not obligatory for memory formation:mice with no adult brain neurogenesis show learning

Udzial regulacji ekspresji genow w procesach integracji informacji w komorkach nerwowych.