Wyniki wyszukiwania

1

Wywazanie walcow maszyn papierniczych nabiera znaczenia ze wzrostem ich predkosci

100%

Sujka M., Marczewska J.

Przegląd Papierniczy

|

1998

|

tom 54

|

nr 04

217-218

2

Studies on the nature of genotoxic and cytotoxic effects induced by hydralazine

100%

Marczewska J., Koziorowska J. H.

Acta Biochimica Polonica

|

1997

|

tom 44

|

nr 2

The nature of genotoxic and cytotoxic effects induced by hydralazine was analyzed taking into account possible protection of cells by catalase, superoxide dismutase and dimethyl sulfoxide. For the experiments designed to evaluate the influence of scavengers on the genotoxicity expressed as the SOS induction factor the E. coli PQ37 strain was used. The cytotoxic effects were investigated in V3 cells cultured in vitro. The genotoxicity and cytotoxicity of hydralazine were suppressed by catalase in a dose-dependent manner but they were enhanced by superoxide dismutase. No protective effect of dimethyl sulfoxide was observed. Our results indicate that H2O2 plays an essential role in the genotoxicity and cytotoxicity of hydralazine.

3

Evaluation of the SOS chromotest for detection of genotoxic drugs

80%

Marczewska J., Chlopkiewicz B., Ejchart A., Koziorowska J.

Acta Microbiologica Polonica

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1993

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tom 42

|

nr 2

4

Studies on the mechanism of mutagenicity and genotoxicity induced by dihydralazine

80%

Chlopkiewicz B., Ejchart A., Marczewska J.

Acta Biochimica Polonica

|

1995

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tom 42

|

nr 3

Dihydralazine was found to be mutagenic towards S. typhimurium TA1537, TA97, TA1538 and TA98 and genotoxic towards E. coli PQ37. Using the nitro blue tetrazolium reduction method we have found that dihydralazine can generate active oxygen species. The possible role of active oxygen species in mutagenicity (Ames test) and genotoxicity (SOS Chromotest) of dihydralazine was studied by testing the influence of the different active oxygen species scavengers on these two processes. Of the active oxygen scavengers tested, only superoxide dismutase suppressed partially the mutagenic and genotoxic activity of dihydralazine. This result seems to indicate that superoxide anion play a role in these two biological events.

5

Contribution of N-oxidation and OH radicals to mutagenesis of 2-chloropyridine in Salmonella typhimurium

71%

Chlopkiewicz B., Wojtowicz M., Marczewska J., Prokopczyk D., Koziorowska J.

Acta Biochimica Polonica

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1993

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tom 40

|

nr 1

Ograniczanie wyników

3 Acta Biochimica Polonica

1 Acta Microbiologica Polonica

1 Przegląd Papierniczy

5 Marczewska J.

3 Chlopkiewicz B.

2 Ejchart A.

2 Koziorowska J.

1 Koziorowska J. H.

1 Prokopczyk D.

1 Sujka M.

1 Wojtowicz M.

1 1998

1 1997

1 1995

2 1993

Wywazanie walcow maszyn papierniczych nabiera znaczenia ze wzrostem ich predkosci

Studies on the nature of genotoxic and cytotoxic effects induced by hydralazine

Evaluation of the SOS chromotest for detection of genotoxic drugs

Studies on the mechanism of mutagenicity and genotoxicity induced by dihydralazine

Contribution of N-oxidation and OH radicals to mutagenesis of 2-chloropyridine in Salmonella typhimurium