The mutual modulatory influence of the connective tissue stroma and tumour parenchyma, with ECM (extracellular matrix) and conecsine gaps has been described. The presence of cellular infiltration in stroma of cancers was also presented. The cellular infiltrations are symptoms of the tissular defence mechanism and/or secondary response on regressive changes such as necrosis and degeneration. They may also be a reaction to the presence of carcinogens. Taking under consideration stroma behaviour, tumours were divided into two groups: tumours producing stroma, i.e. sarcoma and tumours using local tissue, i.e. cancers. Anaplastic (low differentiated) tumours are accompanied by fibroplasia rejuvenation of connective tissue, while in highly differentiated tumours stroma is more like mature connective tissue. This determines the tumour cells’ penetration into stroma, as the more compact the stroma is, the higher propensity to microfocal and dispersed infiltration one may observe. The structure slackening fosters solid multifocal infiltration.
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