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The effect of wortmannin and promoting phorbol ester [TPA] on migration of ovary carcinoma cells

100%

Miloszewska J., Szaniawska B., Kowalczyk D., Janik P.

Cellular and Molecular Biology Letters

1999

tom 04

nr 2

The purpose of the present study was to determine the role of PI 3 kinase in tumor cell migration. The migration of ovary carcinoma cells (OVP10) was strongly inhibited by wortmannin to the same extent as by TPA treatment. The strongest additive inhibitory effect was noted after cell treatment with wortmannin and TPA together. Western blotting studies showed activation / partial down regulation of PKC after TPA treatment and decreased amount of the enzyme following wortmannin exposure. Altogether, it looks like wortmannin inhibits migration of studied cells.

Phosphatidylinositol 3-kinase-like activity in Tetrahymena. Effects of wortmannin and LY 294002

100%

Kovacs P., Pallinger E.

Acta Protozoologica

2003

tom 42

nr 4

Ograniczanie wyników

1 Acta Protozoologica

1 Cellular and Molecular Biology Letters

1 Janik P.

1 Kovacs P.

1 Kowalczyk D.

1 Miloszewska J.

1 Pallinger E.

1 Szaniawska B.

1 2003

1 1999

Wyniki wyszukiwania

The effect of wortmannin and promoting phorbol ester [TPA] on migration of ovary carcinoma cells

Phosphatidylinositol 3-kinase-like activity in Tetrahymena. Effects of wortmannin and LY 294002