The authors tried to determine the role of TH lymphocytes in the course of muscular trichinellosis in mice. The investigations were carried out on the CFW mice infected with 200 Trichinella spiralis larvae and treated with Cyclosporine A to suppresse TH1 lymphocytes. In animals treated with the drug more numerous cells inside the larval capsules and more numerous granulomas compared to control were seen. At the same time the mean number of larvae was lower (69,2%) than in control. The results show that TH1 lymphocytes do not play the significant role in the destruction of muscular larvae. This is the first conclusion and requires of course futher investigations.
Experiments were carried out on male Balb/c mice, weighing 20 g. The Candida cells (Candida albicans L 45) were killed by heat-treatment and obsonized with mouse serum. Macrophages were obtained from the peritoneal cavity. Phagocytosis was executed by incubation 0,2 ml of suspension of macrophages with 0,2 ml of Candida suspension. Microscopic slides with cell smear were preparated. The phagocytic index and the percentage of phagocytizing macrophages were calculeted. It was found that infection with Trichinella spiralis or Trichinella pseudospiralis caused a significant reduction in the phagocytic capacity and the percentage of phagocytizing macrophages. This reduction depended on the intensity of invasion.