Prevalence of multifocal fungal infections in patients undergoing permanent immunosuppresion alter renal transplantation. The aim of the study was to estimate the prevalence of fungi in monofocal and multifocal infections in renal transplant recipients. 32 renal transplant recipients were examined for presence of fungi in genital organs, oral cavity and rectum. Fungal strains were recovered in 66 out of 96 samples (68.2% of all renal transplant recipients) in oral cavity (65.6%), rectum (37.5%) and genital organs (25.0%). Monofocal mycosis was found only in 21.9% of the patients. Multifocal infections occurred in 68.2% and contained ontocenoses of oral cavity and rectum (34.4%) the most frequently. Trifocal infection (genital organs - oral cavity - rectum) occurred in 12.5% of all examined renal transplant recipients. The following fungi were found: Candida albicans (31 strains), C. glabrata (5), C. guilliermondii (2), C. krusei (20, Saccharomyces cerevisiae (1).
The aim was looking for correlation between hydrolytic activity and multifocal Candida invasions in 33 lung cancer patients (LC) before treatment. Materials used in this study were pharyngeal and rectal swab, sputum, bronchial secretion and urine. Isolation and identification of fungi were performed using ID C 32 test and the hydrolytic activity using APIZYM test. Results: 1/ there were only Candida strains, especially C. albicans (78,8 %) isolated. 2/ Candida in more than one sample were present in 74%, in three or four in 27,7% of LC. 3/ Candida strains produced 17 among 19 investigated enzymes. 4/ there were statistically significant correlations between the activity of some hydrolytic enzymes and number of Candida foci observed. Conclusions: 1/ the results confirmed the influence of Candida hydrolytic activity on the course of infcction. 2/ hydrolytic enzymes activity is one of important Candida pathogenicity factors.
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