The aim of the study was to evaluate frequency of occurrence of Chlamydia trachomatis infection in samples of cervical and vulvar cancer in patients of the Lublin Region. The study was performed on paraffin sections prepared from the specimens of cervical cancer obtained from 570 patients and of vulvar cancer from 46 patients. We identified archival diagnostic phase tissue specimens. The control material to that obtained from patients with cervical cancer consisted of normal cervical tissues. The control material to that obtained from patients with vulvar cancer were fragments of normal epithelial tissue collected from the same paraffin blocks containing material from the margin of surgical section during vulvectomy. In order to identify Chlamydia trachomatis, DNA isolated from archival material was analysed and PCR was performed using starters complementary to Chlamydia trachomatis. Statistically significantly higher frequency of the occurrence of Chlamydia trachomatis was observed in sections from patients with invasive cervical cancer compared to control group. In the analysed material, the frequency of cases of vulvar cancer with co-occurrence of Chlamydia trachomatis infection was not statistically significant. Chlamydia trachomatis may not be directly involved in the oncogenic processes but may enhance the possibility of oncogenesis or infect cancer tissues opportunistically.
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.