Wyniki wyszukiwania

1

In vivo reassortment of influenza viruses

100%

Urbaniak K., Markowska-Daniel I.

Acta Biochimica Polonica

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2014

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tom 61

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nr 3

2

Viral genomes and their replication strategies

100%

Lisowski P., Kleczkowski M., Jakubczak A.

Advances in Agricultural Sciences

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2004

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tom 09

3

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Is it possible to order the clusters of viruses and the families of viruses of vertebrates in a way that provides the evolutional connections between the type and the class of nucleic acids forming viral genomes?

100%

Malicki K.

Bulletin of the Veterinary Institute in Puławy

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1998

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tom 42

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nr 1

4

Comparison of the sensitivity and specificity of real-time PCR and in situ hybridization in HPV16 and 18 detection in archival cervical cancer specimens

84%

Biesaga B., Szostek S., Klimek M., Jakubowicz J., Wysocka J.

Folia Histochemica et Cytobiologica

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2012

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tom 50

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nr 2

5

The HPV16 E2 transcriptional regulator mode of action depends on the physical state of the viral genome

84%

Schmidt M. T., Olejnik A. K., Gozdzicka-Jozefiak A.

Acta Biochimica Polonica

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2005

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tom 52

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nr 4

Human papillomavirus (HPV) infection is a major risk factor for the development of cervical cancer. The HPV-induced immortalization of epithelial cell usually requires integration of the viral DNA into the host cell genome. The integration event causes disruption of the E2 gene and this is followed by overexpression of the E6 and E7 oncoproteins. The E2 protein is a transcription factor that regulates expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region. We used an in vitro cell culture model to explore the role of the E2 protein in the transcriptional control of the HPV16 long control region. Employing transient and stable transfection experiments we simulated the episomal and integrated states of the viral genome, respectively. We show that the E2 protein up-regulates E6/E7 transcription from episomal DNA but represses it in the case of integrated DNA. The activator function of the E2 protein seems to counteract the repressive chromatin structure formed over episomal DNA. Steroid hormones and retinol also modulate oncogene transcription differently depending on the physical structure of the viral DNA. Our data suggest regulatory mechanisms involving interactions between the E2 protein and nuclear hormone receptors.

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Advances in Agricultural Sciences

1 Bulletin of the Veterinary Institute in Puławy

1 Folia Histochemica et Cytobiologica

1 Biesaga B.

1 Gozdzicka-Jozefiak A.

1 Jakubczak A.

1 Jakubowicz J.

1 Kleczkowski M.

1 Klimek M.

1 Lisowski P.

1 Malicki K.

1 Markowska-Daniel I.

1 Olejnik A. K.

1 Schmidt M. T.

1 Szostek S.

1 Urbaniak K.

1 Wysocka J.

1 2014

1 2012

1 2005

1 2004

1 1998

In vivo reassortment of influenza viruses

Viral genomes and their replication strategies

Is it possible to order the clusters of viruses and the families of viruses of vertebrates in a way that provides the evolutional connections between the type and the class of nucleic acids forming viral genomes?

Comparison of the sensitivity and specificity of real-time PCR and in situ hybridization in HPV16 and 18 detection in archival cervical cancer specimens

The HPV16 E2 transcriptional regulator mode of action depends on the physical state of the viral genome