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Influence of vagal nerve stimulation on food intake and body weight - results of experimental studies

100%

Sobocki J., Krolczyk G., Herman R. M., Matyja A., Thor P. J.

Journal of Physiology and Pharmacology. Supplement

2005

tom 56

nr 6

27-33

The paper reviews recent advances in vagal nerve stimulation for the control of food intake and body weight. The vagal nerves are the predominant pathway in the "brain-gut axis" responsible for short term regulation of food intake. Stimulation of afferent vagal traffic attenuates food intake by vagal projections to nucleus tractus solitarius, arcuate nucleus and its convergence’s to thalamic center of satiety. A few studies have been published in this field so far. All of them are consistent and show significant decrease in body mass during vagal stimulation. Due to promising results of experimental studies, clinical trials are expected in the near future.

The effects of baclofen on the feeding behaviour and body weight of vagally stimulated rats

100%

Krolczyk G., Laskiewicz J., Sobocki J., Matyja A., Kolasinska-Kloch W., Thor P. J.

Journal of Physiology and Pharmacology

2005

tom 56

nr 1

It is hypothesised that the GABA(B) receptor agonist baclofen increases or has no effect on food intake, and electrical stimulation of vagal nerves decreases food intake. The aim of this study was to evaluate the effects of baclofen in vagally stimulated rats. Material and methods: Thirty two Wistar rats were divided into five groups: group A scheduled for microchip implantation for vagal stimulation, group B for sham operation, group C for microchip implantation and baclofen medication, group D for baclofen medication only and group E for gastric motility evaluation under influence of baclofen. The following parameters were then evaluated: food intake and body mass, gastric motility, leptin, insulin, and glucose serum levels. Results: In the comparison of groups B and A, daily food intake and body weight gain decreased by 17% (p<0.05) and by 22% (p<0.05), respectively. Baclofen alone (group D) did not significantly change either food intake nor diurnal body weight compared to the controls, but when used in conjunction with the microchip (group C) it did significantly reduce effect of vagal neuromodulation (p<0.05). Furthermore, a significant decrease in leptin and glucose levels was detected in group C: 677 to 165 pg/ml (p<0.05) and 5,93 to 4,88 mmol/l (p<0.05), respectively. The administration of baclofen stimulated significantly gastric motility and elicited irregular motor migrating complex (327±200 against control 255±52 cmH2O/s). Conclusions: These results suggest that microchip vagal neuromodulation through increased vagal afferent activity induces an alteration in the feeding behaviour and decreases nocturnal food intake and body weight. These effects were partially attenuated by baclofen. The data suggests that GABA(B) receptors play an important role in the pathomechanism of attenuation of food intake induced by vagal nerve stimulation.

Ograniczanie wyników

1 Journal of Physiology and Pharmacology

1 Journal of Physiology and Pharmacology. Supplement

2 Krolczyk G.

2 Matyja A.

2 Sobocki J.

2 Thor P. J.

1 Herman R. M.

1 Kolasinska-Kloch W.

1 Laskiewicz J.

2 2005

Wyniki wyszukiwania

Influence of vagal nerve stimulation on food intake and body weight - results of experimental studies

The effects of baclofen on the feeding behaviour and body weight of vagally stimulated rats