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Effect of nickel [II] chloride oral exposure on urinary nickel excretion and some other elements

100%

Janicka K., Cempel M.

Polish Journal of Environmental Studies

2003

tom 12

nr 5

Male Wistar rats were given nickel (II) chloride (NiCl2 • 6 H2O) with drinking water (300 or 1200 ppm Ni for 90 days). Urine volume and nickel, zinc, copper, calcium and inorganic phosphorus were measured in 24 h urine after 45 and 90 days of exposure. The results demonstrate that relatively low-level oral exposure (300 ppm Ni) induces an increase of urinary Ni excretion (p < 0.001), but no significant changes in other elements. The higher Ni dose (1200 ppm) caused elevation of this metal in urine (p < 0.001), as well as significant changes of urinary volume, and zinc, copper and inorganic phosphorus concentration.

Ograniczanie wyników

1 Polish Journal of Environmental Studies

1 Cempel M.

1 Janicka K.

1 2003

Wyniki wyszukiwania

Effect of nickel [II] chloride oral exposure on urinary nickel excretion and some other elements