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Polymorphisms in the gene of UCP3 in dairy cattle

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Glosinska J., Kowalewska-Luczak I., Kulig H., Wojdak-Maksymiec K.

Folia Pomeranae Universitatis Technologiae Stetinensis. Agricultura, Alimentaria, Piscaria et Zootechnica

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2015

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tom 36

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The uncoupling protein and alternative oxidase of Dictyostelium discoideum [Mycetozoa] during vegetative life and starvation-induced early development

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Jarmuszkiewicz W., Behrendt M., Hryniewiecka L., Sluse F. E.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

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Correlation of the -3826A G polymorphism in the promoter of the uncoupling protein 1 gene with obesity and metabolic disorders in obese families from Southern Poland

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Kiec-Wilk B., Wybranska I., Malczewska-Malec M., Leszczynska-Golabek I., Partyka L., Niedbal S., Jabrocka A., Dembinska-Kiec A.

Journal of Physiology and Pharmacology

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2002

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tom 53

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nr 3

The aim of the study was to examine the allelic frequency of the -3826A>G mutation of UPC1 in patients with familiar obesity and to investigate putative association of this polymorphism with metabolic disorders. One hundred and eighteen overweight / obese patients participated in the study. The UCP1 polymorphism was determined by RFLP. Glucose, lipid, insulin and leptin levels were measured both during OGTT and OLTT. The majority of patients had a homozygous A/A genotype (51,38%), while 14,68% had a G/G genotype. We found no significant association of the G allele with either BMI or glucose tolerance. Patients with the homozygous G/G genotype had significantly higher fasting levels of TG (p<0.04) and decreased levels of HDL-cholesterol (p=0,004). They also had an increased concentration of FFA and the rise of TG levels during the OLTT compared to controls was significant (p=0,058). In addition, the carriers of the G/G genotype had the lowest insulin levels both during OGTT and OLTT. In our study we have demonstrated that the -3826A>G polymorphism of UCP1 does not play a major role in the development of obesity and/or disturbances of glucose metabolism. However, the increased levels of TG and FFA and decreased levels of HDL observed in carriers of the G allele suggest FFA-induced impairment of the HDL turnover and disturbance of the ß-cell function, both of which are risk factors for endothelial injury.

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The contribution of uncoupling protein and ATP synthase to state 3 respiration in Acanthamoeba castellanii mitochondria

72%

Jarmuszkiewicz W., Czarna M., Sluse-Goffart C., Sluse F. E.

Acta Biochimica Polonica

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2004

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tom 51

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nr 2

Mitochondria of the amoeba Acanthamoeba castellanii possess a free fatty acid-activated uncoupling protein (AcUCP) that mediates proton re-uptake driven by the mitochondrial proton electrochemical gradient. We show that AcUCP activity diverts energy from ATP synthesis during state 3 mitochondrial respiration in a fatty acid-dependent way. The efficiency of AcUCP in mitochondrial uncoupling increases when the state 3 respiratory rate decreases as the AcUCP contribution is constant at a given linoleic acid concentration while the ATP synthase contribution decreases with respiratory rate. Respiration sustained by this energy-dissipating process remains constant at a given linoleic acid concentration until more than 60% inhibition of state 3 respiration by n-butyl malonate is achieved. The present study supports the validity of the ADP/O method to determine the actual contributions of AcUCP (activated with various linoleic acid concentrations) and ATP synthase in state 3 respiration of A. castellanii mitochondria fully depleted of free fatty acid-activated and describes how the two contributions vary when the rate of succinate dehydrogenase is decreased by succinate uptake limitation.

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Uncoupling proteins in mitochondria of plants and some microorganisms

72%

Jarmuszkiewicz W.

Acta Biochimica Polonica

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2001

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tom 48

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nr 1

Uncoupling proteins, members of the mitochondrial carrier family, are present in mitochondrial inner membrane and mediate free fatty acid-activated, purine-nucleo- tide-inhibited H+ re-uptake. Since 1995, it has been shown that the uncoupling protein is present in many higher plants and some microorganisms like non-photosynthetic amoeboid protozoon, Acanthamoeba castellanii and non-fermentative yeast Candida parapsilosis. In mitochondria of these organisms, uncoupling protein activity is revealed not only by stimulation of state 4 respiration by free fatty acids accompanied by decrease in membrane potential (these effects being partially released by ATP and GTP) but mainly by lowering ADP/O ratio during state 3 respiration. Plant and microorganism uncoupling proteins are able to divert very efficiently energy from oxidative phosphorylation, competing for ΔμH+ with ATP synthase. Functional connection and physiological role of uncoupling protein and alternative oxidase, two main energy-dissipating systems in plant-type mitochondria, are discussed.

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Effect of 5-week moderate intensity endurance training on the oxidative stress, muscle specific uncoupling protein (UCP3) and superoxide dismutase (SOD2) contents in vastus lateralis of young, healthy men

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Majerczak J., Rychlik B., Grzelak A., Grzmil P., Karasinski J., Pierzchalski P., Pulaski L., Bartosz G., Zoladz J. A.

Journal of Physiology and Pharmacology

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2010

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tom 61

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