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1

A local pathway for increased testosterone supply from the testis to the epididymis, vas deferens and accessory genital glands of the rat

100%
Krzymowski T., Stefanczyk-Krzymowska S., Gilun P., Radomski M., Koziorowski M.
Polish Journal of Veterinary Sciences
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2005
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tom 08
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nr 3
2

Retrograde transfer of 125I-radiolabelled activin and inhibin in the periovarian vascular complex in the sow

100%
Wasowska B., Stefanczyk-Krzymowska S., Grzegorzewski W.
Polish Journal of Veterinary Sciences
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2009
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tom 12
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nr 2
159-167
This study investigated whether activin A and an inhibin-a subunit fragment (INHα) could permeate in a periovarian vascular complex from ovarian effluent into the ovarian artery and be retrograde transferred into the ovary. Radiolabelled activin A (125I-activin A) and INHα (125I-INHα) were injected (2.7xl07 dpm) into follicles or corpora lutea (CL). It was demonstrated that 125I-activin A and 125I-INHa were released into the ovarian effluent and permeated into the arterial blood supplying the ovary in both phases of the cycle. The concentration of 125I-activin A in ovarian arterial blood was higher in the luteal phase (LP) than in the follicular phase (FP) (P<0.0001) in contrast to 125I-INHα which was higher in the FP (P<0.0001). The concentration of 125I-activin A in uterine tissues generally did not differ between the phases of the estrous cycle, but the concentration of 125I-INHα was higher (P<0.05) in the FP than in the LP. The concentration of 125I-activin A was higher in the LP in samples of endometrium and myometrium (P<0.05), as well as mesometrium (P<0.01), and higher in the FP in samples of mesometrium (P<0.05) close to the ovary than in the samples adjoining the uterine body. In the FP, the concentration of 125I-INHa was higher in endometrium and mesometrium close to the ovary than in samples adjoining the uterine body (P<0.05). In conclusion, the study demonstrated that it was possible for INHa and activin A to be retrograde transferred to the ovary. Thus this transfer could elevate their concentration in arterial blood supplied to the ovarian follicles or CL and may influence production of these peptides in the ovary, modulating ovarian function.
3
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Density of tumor-associated macrophages (TAMs) and expression of their growth factor receptor MCSF-R and CD14 in canine mammary adenocarcinomas of various grade of malignancy and metastasis

100%
Krol M., Pawlowski K., Majchrzak K., Dolka I., Abramowicz A., Szyszko K., Motyl T.
Polish Journal of Veterinary Sciences
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2011
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tom 14
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nr 1
Several years ago, the presence of macrophages in the tumor microenvironment was thought to be an inflammatory response to kill the cancer cells. Now, this is clear that the inflammatory cells that exit blood vessels and migrate to the tumor tissue play an important role in cancer progression. Various cells present in the tumor microenvironment enhance cancer growth and invasiveness by secretion of tumor-enhancing products. That is why tumors should not be treated as only aggregates of cancer cells but as separate structures. Macrophages form a major component of the inflammatory infiltration in tumors, where they are termed tumor-associated macrophages (TAMs). To the best of our knowledge, up-to-date there were no studies on tumor associated macrophages and the role of the tumor microenvironment in tumor invasion/metastasis in dogs. This is the first study performed to asses if the number of TAMs and expression of MCSF-R (macrophages colony stimulating factor receptor) and CD14 (LPS co-receptor) are associated with the grade of tumor malignancy and its ability to metastasize. We have performed immunohistochemical analysis of 50 canine mammary adenocarcinomas of various grade of malignancy (1st, 2nd, 3rd) and tumors that gave local or distant metastases. The results indicate that in dogs, similarly to humans and mice, the number of tumor associated macrophages is related to the cancer ability to metastasize. Our results also indicate that the expression of MCSF-R and, what is particularly new finding, CD14 is associated with tumor malignancy and its ability to metastasize. Hence, these molecules play a role in tumor progression, metastasis and microenvironment interactions. These results show that in dogs we should treat the tumor as a whole organ rather than just try to eliminate the cancer cells.
4

Laparoscopic biopsy of the stomach and duodenum

100%
Chyczewski M., Adamiak Z., Holak P., Jalynski M., Pesta W.
Bulletin of the Veterinary Institute in Puławy
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2011
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tom 55
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nr 1
The objective of this study was to evaluate the usefulness of the laparoscopic technique for performing a biopsy of the gastric and duodenal wall in dogs. Endoscopic examinations were performed in five dogs, which were not conclusively diagnosed based on symptoms and the results of clinical and laboratory tests. A histopathological analysis of laparoscopically collected tissue samples supported the diagnosis of a chronic inflammation of the gastric and duodenal wall. The results of the experiment indicate that laparoscopy permits accurate mapping of the biopsy site and supports the collection of tissue samples for histopathological analyses.
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