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1

Thyroid function in patients with Alzheimer's disease treated with cholinesterase inhibitors

100%
Kapaki E., Ilias I., Paraskevas G. P., Theotoka I., Christakopoulou I.
Acta Neurobiologiae Experimentalis
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2003
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tom 63
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nr 4
2
Content available remote

Vasopressin and oxytocin release and the thyroid function

86%
Ciosek J., Drobnik J.
Journal of Physiology and Pharmacology
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2004
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tom 55
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nr 2
The aim of the present investigations was to examine the effects of the states of hypothyroidism or hyperthyroidism on vasopressin (AVP) and oxytocin (OT) release under conditions of equilibrated water metabolism as well as of osmotic stimulation, brought about by the dehydration or hypertonic saline administration. The euhydrated and simultaneously hypothyroid rats showed decreased hypothalamic AVP and OT content and somewhat higher but not significant neurohypophysial AVP content. In these animals the raised OT (but not AVP) plasma level has been observed. In hyperthyroid rats drinking tap water ad libitum the neurohypophysial AVP and OT content significantly diminished; plasma OT concentration (but not AVP) was then elevated. The state of osmotic stimulation was the reason of different response of the hypothalamo-neurohypohysial system function in hypo- or hyperthyroid rats. Significant decreases of neurohypophysial AVP and OT content were found in both hypothyroid dehydrated as well as hypothyroid hypertonic saline-treatment rats as compared with hypothyroid euhydrated ones. On the contrary, in the state of hyperthyroidism AVP content in the neurohypophysis distinctly raised in dehydrated and salt-loaded rats; in these last neurohypophysial OT content increased as well. Plasma OT (but not AVP) distinctly diminished in hyperthyroid and simultaneously dehydrated or hypertonic saline injected rats in relation to hyperthyroid control subgroup. Data from the present study suggest that: 1) altered thyroid gland function affects vasopressin and oxytocin release from the hypothalamo-neurohypophysial system in the state of equilibrated water metabolism; 2) the state of hypo- or hyperthyroidism modifies the response of AVP-ergic and OT-ergic neurons upon the osmoreceptors/osmodetectors stimulation. It may be sypposed that OT-ergic neurons display greater than AVP-ergic neurons sensitivity upon the thyroid hormone influence.
3

Influence of cyclosporine A on thyroid function in the experimental autoimmune thyroiditis [EAT] in mice

58%
Czyzyk J. K., Jakobisiak M.
Archivum Immunologiae et Therapiae Experimentalis
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1995
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tom 43
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nr 1
4

Changes in periestrous hormonal profile in blood of gilts with different thyroid function and ovarian cysts

58%
Fitko R., Jana B., Kucharski J., Sobczak J.
Polish Journal of Veterinary Sciences
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1998
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tom 01
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nr 1
The subject of this wprk was the investigation of luteinizing hormone, progesterone, testosterone and total estrogens concentration in the peripheral plasma of 56 gilts with experimentally-induced hypo- and hyperthyroidism and with ovarian cystic degeneration. The blood samples were collected from the cannulated jugular vein at 19-23 days after last natural estrus, 5-10 times daily. The experiments resulted in significant deviations in plasma hormone profile during the periestrous period. The hypothyroid gilts showed a significant increase but hyperthyroid animals a decrease in level of LH accompanied by a significant peak of estrogens on the 22nd day of cycle. The cyst-bearing gilts exhibited a decreased level of LH, an increased concentration of progesterone and a changeable content of estrogens. It may be suggested that abnormalities in hormonal pattern in experimental gilts were caused by derangement of functional interrelationships in the pituitary-thyroid-ovarian axis which influence sex hormone synthesis and release.
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