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Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum

100%

Blaszkowska J.

Wiadomości Parazytologiczne

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2002

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tom 48

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nr 1

It bas been found that trypsin and α-chymotrypsin inhibitors isolated from Ascaris suum act embryotoxically and teratogenically on White Leghorn clucken embryos. Mortatity rate for the chicken embryos on day 15 of incubation was 45.0 ± 3.5% after injection of trypsin inbibitor and 44.0 ± 3.5% after adminstration α-chymotrypsin inbibitor. Gross examination of surviving embryos and their dissection revealed pathological changes (abdominal dropsy, umbilical hernia, subcutaneous oedema, hemoperitoneum, hemopericardium), symptoms indicating retardation in growth (lack of down, retarded ossification of long bones, decreased mean body weight) as well as malformations (schistocelia, micrognathia, cyclopia, crossed beak, cranial deformities) after injection of inhibitors from Ascaris. The highest incidence of embryos with pathological changes and malformations was found after administralion of α-chymotrypsin inbibitor. The most commonly occurring abnormality was schistocelia (21.4 ± 3.88%). Growth malformations were not found in the control groups. The trypsin and α-chymotrypsin inhibitors present in Ascaris homogenate have a significant disturbing effect on the development of the chicken embryo.

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Somatic and skeleton development of rat foetuses following in-utero exposure to isopropylantipyrine [propyphenazone] during the second trimester of gestation

84%

Burdan F.

Folia Morphologica

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2000

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tom 59

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nr 4

Isopropylantipyrine (IPA, propyphenazone) is a pyrazolone derivative, widely used as an antipyretic and analgesic drug. The aim of the study was to evaluate the influence of propyphenazone on rat development. IPA was administered to pregnant rats from day 8 to day 14 of pregnancy once a day, orally by a stomach tube at doses of 2.10 (R1), 21.0 (R2), and 210.0 mg/kg/day (R3). The dams were sacrificed on day 21 of gestation and corpora luteum, implants, resorptions, and live foetuses were counted. The weight of foetuses and placentas, the length of foetuses and their tails were checked. The foetuses were fixed in alcohol and skeletons were stained with alizarin. There was a statistical difference in body length in R1, R2 and numbers of subcutaneous ecchymose in R1. External and skeletal examination of the foetuses revealed no evidence of teratogenesis. It can be concluded that IPA has no harmful effects on the prenatal development of the rat offspring at doses used in the present study.

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Identification of teratogens in cell culture. II. Laboratory values of rat embryo midbrain studied by micromass test with penicillin G and 5-fluorouracil

67%

Minta M.

Bulletin of the Veterinary Institute in Puławy

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2003

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tom 47

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nr 2

Ograniczanie wyników

1 Bulletin of the Veterinary Institute in Puławy

1 Folia Morphologica

1 Wiadomości Parazytologiczne

1 Blaszkowska J.

1 Burdan F.

1 Minta M.

1 2003

1 2002

1 2000

Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum

Somatic and skeleton development of rat foetuses following in-utero exposure to isopropylantipyrine [propyphenazone] during the second trimester of gestation

Identification of teratogens in cell culture. II. Laboratory values of rat embryo midbrain studied by micromass test with penicillin G and 5-fluorouracil