DNA fingerprinting patterns (DFPs) obtained by multi-locus probes have been shown to be useful in assessing genetic variation and genetic distances in laboratory animals. Using this method DFP profiles were analysed of mice belonging to lines divergently selected over 56 generations for high (HA) and low (LA) swim stress-induced analgesia. Apart from nociception-related traits the HA mice displayed, as compared to the LA animals, higher emotionality in various behavioural tests, and higher degree of hypothermia when subjected to a hypothermic challenge. In earlier study the authors showed that HA mice appeared to be more susceptible to the mutagenic effect of whole-body ă-radiation and mitomycin C injection. Lower nucleolar organizer regions (NOR) activity was also observed. In the present study the use of DFP method demonstrated that selection for magnitude of swim stress-induced analgesia differentiated the parental outbred population into two distinct genotypem characterized by specific minisatellite sequences for each line that may be genetic markers for particular physiological and neuro-behavioural traits. It is concluded that the selection altered the frequencies of minisatellites which are linked to genes determining susceptibility to stress, resulting in differentiation of stress-related traits.
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