The aim of the present study was to determine the concentration of C-reactive protein (CRP) and serum amyloid A (SAA) in bitches suffering from spontaneously occurring mammary gland tumors. The experiment involved 30 bitches with malignant gland tumors removed surgically (carcinoma complex - 40%, carcinoma simple - 26.7%, sarcoma - 23.3%, carcinosarcoma - 10%) and 10 clinically healthy bitches. Measurements of the CRP and SAA serum concentration were performed using a commercial ELISA test. The concentration of CRP as well as SAA were significantly higher in bitches with sarcomas or carcinosarcomas compared with the animals with carcinomas (complex or simple) and the control group. Histopathological examination showed extensive areas of necrosis and inflammatory reactions in most sarcomas and carcinosarcomas. Most likely these were the main causes of the CRP and SAA increase in the serum of bitches with these type of tumors.
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