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Wplyw glodzenia na dystrybucje sulfamerazyny podawanej dozylnie u owiec

100%

Garwacki S., Karlik W., Rutkowski J., Wiechetek M.

Medycyna Weterynaryjna

1993

tom 49

nr 05

221-223

The experiments were carried out on 8 mature ewes fed ad libitum or being on starvation diet. Sulfamerazine was administered at a dose of 60 mg per 1 kg of body weight intravenously. During starvation the biological half-life of sulfamerazine in the blood plasma was prolonged (not significantly). The results of sulphonamide determinations in the rumen contents of sheep showed that a significant amount of the drug administered intravenously penetrated to the forestomachs and its amount was much higher in the rumen contents of starved sheep than in those fed ad libitum; beginning from the 10th hour after sulfamerazine administration its level was much higher in the rumen contents than in the blood plasma. On the basis of the results one can claim that sulfamerazine concentration in the forestomachs is depending not so much on its increased inflow into the forestomachs as on a decreased outflow related with the pH value of the forestomach contents. Due tо a high level of sulphamides in the forestomachs of starved ruminants the rate of their elimination from the body can be diminished.

Analiza farmakokinetyczna stężeń sulfamerazyny i diawerdyny w surowicy cieląt po stosowaniu preparatu "Diamerazin" celem wyznaczenia okresu karencji

51%

Kowalski C.

Annales Universitatis Mariae Curie-Skłodowska. Sectio DD:Medicina Veterinaria

1988

tom 43

Ograniczanie wyników

1 Annales Universitatis Mariae Curie-Skłodowska. Sectio DD:Medicina Veterinaria

1 Medycyna Weterynaryjna

1 Garwacki S.

1 Karlik W.

1 Kowalski C.

1 Rutkowski J.

1 Wiechetek M.

1 1993

1 1988

Wyniki wyszukiwania

Wplyw glodzenia na dystrybucje sulfamerazyny podawanej dozylnie u owiec

Analiza farmakokinetyczna stężeń sulfamerazyny i diawerdyny w surowicy cieląt po stosowaniu preparatu "Diamerazin" celem wyznaczenia okresu karencji