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Molecular target analysis of stearoyl-CoA desaturase genes of protozoan parasites

100%

Lu H., Qin X., Zhang J., Zhang S., Zhu Y., Wu W. H.

Acta Parasitologica

2018

tom 63

nr 1

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Variation in the activity of stearoyl-CoA desaturase enzyme and endogenous precursors of unsaturated fatty acids in cow's milk during grazing season

100%

Kuczynska B., Puppel K., Nalecz-Tarwacka T., Czub M.

Annals of Warsaw University of Life Sciences - SGGW. Animal Science

2015

tom 54[1]

Variation in the activity of stearoyl-CoA desaturase enzyme and endogenous precursors of unsaturated fatty acids in cow's milk during grazing season. The aim of this study was to determine variation in the activity of stearoyl-CoA desaturase enzyme and endogenous precursors of unsaturated fatty acids in cow's milk during the grazing season. The study was carried out in 10 certified organic farms The major criterions of choosing organic farms to the experiment were as follows: obtaining certificate for at least 5 years and abidance of the organic farming standards, possessing a herd of Black and White Polish Holstein-Friesian cows (numbering more than 30 cow. The highest concentrations of CLA cis9, trans11 isomer, TVA and LA in milk fat has been reported in June, slightly lower in July and August. While the lowest level has been recorded in May, at the beginning of grazing period. Significant correlations between MUFA and SCD (r2= 0.828 p<0.01) has been recorded. We concluded, that monitoring of SCD activity can be used as a tool to achieve high unsaturation of milk fat, during grazing period.

Prominent role of liver in elevated plasma palmitoleate levels in response to rosiglitazone in mice fed high-fat diet

67%

Kuda O., Stankova B., Tvrzicka E., Hensler M., Jelenik T., Rossmeisl M., Flachs P., Kopecky J.

Journal of Physiology and Pharmacology

2009

tom 60

nr 4

135-140

In humans, antidiabetics thiazolidinediones (TZDs) upregulate stearoyl-CoA desaturase 1 (SCD1) gene in adipose tissue and increase plasma levels of Scd1 product palmitoleate, known to enhance muscle insulin sensitivity. Involvement of other tissues in the beneficial effects of TZDs on plasma lipid profile is unclear. In our previous study in mice, in which lipogenesis was suppressed by corn oil-based high-fat (cHF) diet, TZD rosiglitazone induced hepatic Scd1 expression, while liver triacylglycerol content increased, VLDL-triacylglycerol production decreased and plasma lipid profile and whole-body glycemic control improved. Aim of this study was to characterise contribution of liver to changes of plasma lipid profile in response to a 8-week-treatment by rosiglitazone in the cHF diet-fed mice. Rosiglitazone (10 mg/kg diet) upregulated expression of Scd1 in various tissues, with a stronger effect in liver as compared with adipose tissue or skeletal muscle. Rosiglitazone increased content of monounsaturated fatty acids in liver, adipose tissue and plasma, with palmitoleate being the most up-regulated fatty acid. In the liver, enhancement of Scd1 activity and specific enrichment of cholesteryl esters and phosphatidyl cholines with palmitoleate and vaccenate was found, while strong correlations between changes of various liver lipid fractions and total plasma lipids were observed (r=0.74-0.88). Insulin-stimulated glycogen synthesis was increased by rosiglitazone, with a stronger effect in muscle than in liver. Conclusions: changes in plasma lipid profile favouring monounsaturated fatty acids, mainly palmitoleate, due to the upregulation of Scd1 and enhancement of Scd1 activity in the liver, could be involved in the insulin-sensitizing effects of TZDs.

Ograniczanie wyników

1 Acta Parasitologica

1 Annals of Warsaw University of Life Sciences - SGGW. Animal Science

1 Journal of Physiology and Pharmacology

1 Czub M.

1 Flachs P.

1 Hensler M.

1 Jelenik T.

1 Kopecky J.

1 Kuczynska B.

1 Kuda O.

1 Lu H.

1 Nalecz-Tarwacka T.

1 Puppel K.

1 Qin X.

1 Rossmeisl M.

1 Stankova B.

1 Tvrzicka E.

1 Wu W. H.

1 Zhang J.

1 Zhang S.

1 Zhu Y.

1 2018

1 2015

1 2009

Wyniki wyszukiwania

Molecular target analysis of stearoyl-CoA desaturase genes of protozoan parasites

Variation in the activity of stearoyl-CoA desaturase enzyme and endogenous precursors of unsaturated fatty acids in cow's milk during grazing season

Prominent role of liver in elevated plasma palmitoleate levels in response to rosiglitazone in mice fed high-fat diet