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Potential possibilities of using phage typing in elimination of multidrug resistant staphylococci

100%

Drulis-Kawa Z., Weber-Dabrowska B., Lusiak-Szelachowska M., Doroszkiewicz W.

Polish Journal of Microbiology

2005

tom 54

nr 1

Coagulase-negative staphylococci (CoNS) have become the most often isolated bacteria from blood culture, spinal fluid and respiratory tracts of neonates. These nosocomial strains are often resistant to oxacillin and other antibiotics (macrolides, aminoglycosides and fluorochinolones). 50 multidrug resistant CoNS strains isolated from bloodstream neonatal infections were tested for sensitivity to 23 lytic staphylococcus bacteriophages. No lytic patterns for 19 of the phages were observed. Phages P4, A3R and 676/Z were active against 46%, 54% and 56% of the strains, respectively. In general, 60% of CoNS isolates were susceptible to one or more of the staphylococcus bacteriophages.

Experimental toxoplasmosis of the central nervous system in rabbits as a model of human infection

80%

Dzbenski T. H., Bitkowska E., Golab E., Waloch M.

Acta Parasitologica

1998

tom 43

nr 3

Rabbits were infected by intraventricular injection of tachyzoites of the RH strain of Toxoplasma gondii and examined for a laboratory evidence of toxoplasmosis at the advanced stage of infection. From the examined samples of cerebrospinal fluid (CSF), blood and brain sections, the samples of spinal fluid appeared frequently negative for toxoplasmosis in spite of very sensitive methods that had been used in the diagnostic procedure. Most probable explanation of the low efficiency of diagnostic methods based on examination of the spinal fluid was a slow circulation of the CSF, which did not promote dissemination of parasites within cerebral ventricles and subarachnoid spaces. The results of the studies allowed to conclude that rabbits infected by intraventricular injection of T. gondii provide a good model of toxoplasmosis of the central nervous system which may facilitate evaluation of the efficiency of diagnostic procedures used to differentiate the condition.

Ograniczanie wyników

1 Acta Parasitologica

1 Polish Journal of Microbiology

1 Bitkowska E.

1 Doroszkiewicz W.

1 Drulis-Kawa Z.

1 Dzbenski T. H.

1 Golab E.

1 Lusiak-Szelachowska M.

1 Waloch M.

1 Weber-Dabrowska B.

1 2005

1 1998

Wyniki wyszukiwania

Potential possibilities of using phage typing in elimination of multidrug resistant staphylococci

Experimental toxoplasmosis of the central nervous system in rabbits as a model of human infection