Detailed recognition of weed infestation state and degree in south-western region of Poland provided the basis for starting field experiment on three types of soils aiming at the assessment of weed control effectiveness by means of suitably selected herbicide systems. High efficiency of weed elimination on alluvial soils was obtained due to herbicide mixture mesotrione + nicosulfuron in split doses. In the experiment established on brown soils the mentioned weed species were most satisfactorily controlled by herbicide mixture applied according to infestation degree: mesotrione + nicosulfuron i rimsulfuron + adjuvant + dicamba applied once in full doses. The mixture rimsulfuron + adjuvant + dicamba showed to be the most efficient regarding the weeds typical for alluvial soils, except for Elymus repens, numerously occurring in the experiment, which exhibited medium sesitivity, as well as winter forms of Anthemis arvensis. Mixture of rimsulfuron + adjuvant + florasulam + 2,4- D allowed to eliminate undesired plants on that soil stand in the most efficient way and to achieve the highest grain yield.