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Chemopreventive effects of Calluna vulgaris and Vitis vinifera extracts on UVB-induced skin damage in SKH-1 hairless mice

100%

Filip A., Clichici S., Daicoviciu D., Catoi C., Bolfa P., Postescu I. D., Gal A., Baldea I., Gherman C., Muresan A.

Journal of Physiology and Pharmacology

2011

tom 62

nr 3

Solar ultraviolet radiation (UV) is a major cause of non-melanoma skin cancer in humans. Photochemoprevention with natural products represents a simple but very effective strategy in the management of cutaneous neoplasia. The study investigated the protective activity of Calluna vulgaris (Cv) and red grape seeds (Vitis vinifera L, Burgund Mare variety) (BM) extracts in vivo on UVB-induced deleterious effects in SKH-1 mice skin. Forty SKH-1 mice were randomly divided into 4 groups (n=10): control, UVB irradiated, Cv + UVB irradiated, BM+UVB irradiated. Both extracts were applied topically on the skin in a dose of 4 mg/40 µl/cm2 before UVB exposure - single dose. The effects were evaluated in skin 24 hours after irradiation through the presence of cyclobutane pyrimidine dimers (CPDs) and sunburn cells, tumor necrosis factor-alpha (TNF-), interleukin (IL)-6 levels. The antioxidant activity of BM extract was higher than those of Cv extract as determined using stable free radical DPPH assay and ABTS test. One single dose of UVB generated formation of CPDs (p<0.0001) and sunburn cells (p<0.0002) and increased the cytokine levels in skin (p<0.0001). Twenty hours following irradiation BM extract inhibited UVB-induced sunburn cells (p<0.02) and CPDs formation (p<0.0001). Pretreatment with Cv and BM extracts resulted in significantly reduced levels of IL-6 and TNF- compared with UVB alone (p<0.0001). Our results suggest that BM extracts might be a potential candidate in preventing the damages induced by UV in skin.

Chicks from synchronized groups show less feather pecking as adults

88%

Jensen A. B., Forkman B.

Animal Science Papers and Reports. Supplement

2005

tom 23

nr 1

Ograniczanie wyników

1 Animal Science Papers and Reports. Supplement

1 Journal of Physiology and Pharmacology

1 Baldea I.

1 Bolfa P.

1 Catoi C.

1 Clichici S.

1 Daicoviciu D.

1 Filip A.

1 Forkman B.

1 Gal A.

1 Gherman C.

1 Jensen A. B.

1 Muresan A.

1 Postescu I. D.

1 2011

1 2005

Wyniki wyszukiwania

Chemopreventive effects of Calluna vulgaris and Vitis vinifera extracts on UVB-induced skin damage in SKH-1 hairless mice

Chicks from synchronized groups show less feather pecking as adults