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1
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Side effects of fungicides and insecticides on entomopathogenic fungi in vitro

100%
Fiedler Z., Sosnowska D.
Journal of Plant Protection Research
|
2017
|
tom 57
|
nr 4
Products based on different strains of entomopathogenic fungi are now being used in Integrated Pest Management (IPM) programs. Compatibility studies of chemical and biological control agents are necessary to be able to give proper recommendations for their integrated use. The effect of three insecticides based on imidacloprid, spinosad and abamectin, and three fungicides based on chlorothalonil, azoxystrobin and thiophanate-methyl on the activity of the following entomopathogenic fungi: Metarhizium anisopliae (Metschn.) sensu lato, Beauveria bassiana (Bals.-Criv.) Vuill., Acremonium sp. was tested under laboratory conditions. Tests of the influence of the pesticides on growth and production of conidia were performed. From this study, we concluded that all tested insecticides can be applied together with fungus B. bassiana products in IPM programs. They even stimulate sporulation of this fungus at the recommended dose, 0.5 of the recommended dose and 1.5 times the recommended dose. In the case of fungicides we observed inhibition of growth and sporulation of B. bassiana and reduction of growth and sporulation of other species of fungi.
2
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Identification of potential off-targets of chemotherapeutic agent Sorafenib: a molecular docking approach

100%
Sahrawat T. R., Chawla P.
International Letters of Natural Sciences
|
2016
|
tom 51
B-Raf is a multi- drug target serine/threonine protein kinase, involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Mutated B-Raf causes overactive downstream signaling via MEK and ERK, leading to excessive cell proliferation and survival, independent of growth factors causing cancers such as Pancreatic carcinoma. A novel bi-aryl urea- Sorafenib, is a potent inhibitor of Raf-1 that has been approved for the treatment of a number of cancers including pancreatic cancer. The present investigation was designed to identify the potential off-targets of Sorafenib which could be responsible for its reported undesirable side effects. Molecular docking was used to test the efficacy of structural analogs of Sorafenib against B-Raf using FlexX and it was found that the analog with CID:10151557 had a high potency with minimum number of clashes, low lipophilic score and high match score, similar to Sorafenib. To identify the potential off-target/s of Sorafenib, macromolecular surface similarity detection software MEDIT SA MED-SuMo was used and the results obtained were validated through literature. The possible off-targets obtained belonged to the family of protein tyrosine kinases i.e. VEGFR-2, VEGFR-3, platelet-derived growth factor receptor beta, Flt-3, and c-KIT, each of which were docked with Sorafenib. Based on high docking scores and similarity with B-Raf for its binding site interacting residues, it was concluded that Vascular endothelial growth factor tyrosine kinase receptor (VEGFR) is a potential off-target of anti-cancer chemotherapeutic agent Sorafenib.
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Circulation of pesticides in agrocenosis

84%
Wegorek W.
Prace Naukowe Instytutu Ochrony Roślin
|
1980
|
tom 22
|
nr 2
4

Overuse of high stability antibiotics and its consequences in public and environmental health

84%
Zdziarski P., Simon K., Majda J.
Acta Microbiologica Polonica
|
2003
|
tom 52
|
nr 1
5

Bifosfoniany - kontrowersyjny problem w leczeniu koni

67%
Kane E.
Weterynaria po Dyplomie
|
2019
|
tom 20
|
nr 6
6

Perspektywy i ograniczenia wykorzystania bioinsektycydow w rolnictwie ekologicznym

67%
Kuhne S.
Progress in Plant Protection
|
2008
|
tom 48
|
nr 4
1309-1313
7

Ocena wplywu interferonu ALFA na przebieg choroby nowotworowej u dzieci ze zlosliwymi guzami litymi

59%
Balcerska A., Bohdan Z., Drozynska E., Kozielska E., Szarszewski A., Sierota D.
Acta Biologica et Medica
|
1993
|
tom 20
61-70
8

Wplyw chemicznej ochrony upraw pszenicy ozimej i rzepaku ozimego na dynamike liczebnosci epigeicznej fauny stawonogow

51%
Solowski A.
Progress in Plant Protection
|
1996
|
tom 36
|
nr 2
69-71
9

Side effects of two insecticides [Ambusz 25 EC and Ripcord 40 EC] on the activity of nitrate reductase and content of some components in pea [Pisum sativum L.] leaves

51%
Radwan-Kaznica M., Rozek S., Strzetelski P.
Acta Agraria et Silvestria. Series Agraria
|
1994
|
tom 32
67-74
Results of 3-years investigations on changes in the activity of nitrate reductase and the content of nitrates, water soluble sugars, and starch in leaves of plants of two pea cultivars treated with Ambusz 25 EC (permetrin) and Ripcord 40 EC (cypermetrin) were presented. It was found that the applied insecticides brought about the greatest changes in the activity or nitrate reductase and in the content of nitrates. Of the two cultivars investigated Beniaminek manifested a stranger susceptibility to the applied insecticides. Side effects of pyretroids depend on the stages of plant development, the greatest effect being observed at the stage of technological maturity of pea seeds.
10

Pesticide side effect on the symbiotic efficiency and nitrogenase activity of Rhizobiaceae bacteria family

51%
Niewiadomska A., Klama J.
Polish Journal of Microbiology
|
2005
|
tom 54
|
nr 1
The laboratory experiments tested the influence of selected pesticides on the symbiotic efficiency and nitrogenase activity of Rhizobium teguminosarum bv. trifolii KGL, Sinorhizobium melilotii Bp and Bradyrhizobium sp. Ornithopus B bacteria entering into symbiosis with clover, lucerne and serradella, respectively. The results obtained indicate that the pesticides used in the experiments (Funaben T seed dressing and Pivot 100SL herbicide) caused reduced nitrogenase activity in active strains tested. In addition, a toxic effect of the applied pesticides on the nodulation and root growth of the tested plants was observed.
11

Drobne bezkregowce glebowe - bioindykatory w uprawach pszenicy i rzepaku

43%
Grabarkiewicz A., Trojanowski H.
Progress in Plant Protection
|
1996
|
tom 36
|
nr 2
72-75
12

Bioroznorodnosc a ochrona lasu przed szkodliwymi owadami

43%
Malinowski H.
Progress in Plant Protection
|
2006
|
tom 46
|
nr 1
319-325
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