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Some results of an analysis of polyhydric alcohols effect on detoxication processes

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Konovchuk V., Andrushchak A.

Health Problems of Civilization

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2015

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tom 09

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nr 2

Rheosorbilact action on antitoxic function of the kidneys has been analysed using the values of medium weight molecules in patients with severe sepsis. The study design includes the criteria of inclusion, exclusion and cessation. Patients with pyoceptic complications (mainly surgical abdominal sepsis) with signs of severe endotoxicosis, dopaminergic activity (5-10 mcg/kg min), biochemical criteria of SS (lactate >4 mmole/l, С-reactive protein >2 standard departures from the norm) and other signs of severe sepsis with generalized disorders in homeostasis (assessing the multiple organ damage course by H.Celye-I.A. Yeriuhin scale- 20-27 points, MODS scale – 6-10 points) corresponded to the inclusion criterion. All patients were provided with appropriate debridement and intensive traditional therapy. For control studies we involved patients with systemic inflammatory response syndrome who had 2-3 signs of SIRS in stage A. It was found that rheosorbilact activates the transportation of medium weight molecules out of the extracellular space and increases their excretion by the renal nephrons in patients with severe sepsis. It was established that in severe sepsis rheosorbilact provides a high level of excretion of medium weight molecules by suppressing processes of reabsorption in the proximal nephron portions caused by peptidase dependent metabolism.

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Immune balance in critically ill patients

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Pinsky M. R.

Archivum Immunologiae et Therapiae Experimentalis

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2000

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tom 48

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nr 6 Spec.Iss.

439-442

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Soluble TREM-1 serum level can early predict mortality of patients with sepsis, severe sepsis and septic shock

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Jedynak M., Siemiatkowski A., Mroczko B., Groblewska M., Milewski R., Szmitkowski M.

Archivum Immunologiae et Therapiae Experimentalis

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2018

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tom 66

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nr 4

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N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels septic patients

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Piechota M., Banach M., Irzmanski R., Misztal M., Rysz J., Barylski M., Piechota-Urbanska M., Kowalski J., Pawlicki L.

Cellular and Molecular Biology Letters

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2007

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tom 12

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nr 2

The aim of this study was to find the relationship between N-terminal brain natriuretic propeptide (NT-proBNP), procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in septic patients. This was a prospective study, performed at Medical University Hospital No. 5 in łódź. Twenty patients with sepsis and severe sepsis were included in the study. N-terminal brain natriuretic propeptide, procalcitonin and C-reactive protein concentrations, and survival were evaluated. In the whole studied group (128 measurements), the mean NT-proBNP, procalcitonin and C-reactive protein concentrations were, respectively: 140.80±84.65 pg/ml, 22.32±97.41 ng/ml, 128.51±79.05 mg/l. The correlations for the NT-proBNP level and procalcitonin and C-reactive protein levels were 0.3273 (p<0.001) and 0.4134 (p<0.001), respectively. NT-proBNP levels correlate with PCT and CRP levels in septic patients. In the survivor subgroup, the mean NT-proBNP plasma concentrations were significantly lower than in the non-survivor subgroup.

Ograniczanie wyników

2 Archivum Immunologiae et Therapiae Experimentalis

1 Cellular and Molecular Biology Letters

1 Health Problems of Civilization

1 Andrushchak A.

1 Banach M.

1 Barylski M.

1 Groblewska M.

1 Irzmanski R.

1 Jedynak M.

1 Konovchuk V.

1 Kowalski J.

1 Milewski R.

1 Misztal M.

1 Mroczko B.

1 Pawlicki L.

1 Piechota M.

1 Piechota-Urbanska M.

1 Pinsky M. R.

1 Rysz J.

1 Siemiatkowski A.

1 Szmitkowski M.

1 2018

1 2015

1 2007

1 2000

Some results of an analysis of polyhydric alcohols effect on detoxication processes

Immune balance in critically ill patients

Soluble TREM-1 serum level can early predict mortality of patients with sepsis, severe sepsis and septic shock

N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels septic patients