Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: serum response factor

Sortuj według:

Ogranicz wyniki do:

Expression of serum response factor in normal rat gastric mucosa

100%

Chai J., Baatar D., Moon W., Tarnawski A.

Journal of Physiology and Pharmacology

2002

tom 53

nr 2

Serum response factor (SRF) is a transcription factor that is involved in cell proliferation, muscle and neuron development and maintenance. Its expression in gastric mucosa remains unknown. In this study we demonstrated that SRF is expressed in normal rat gastric tissue as two isoforms and localized mainly to smooth muscle cells of muscularis mucosae and its extensions into the lamina propria, to muscularis propria, and musculature of the vascular system. To a lesser extent, SRF is also expressed in the gastric epithelium of the mucosal neck area (proliferative zone) and in the endothelial cells of microvessels. These data suggest that the main role of SRF in normal gastric tissue is to maintain muscular support and contraction and possibly epithelial regeneration.

Serum response factor: discovery, biochemistry, biological roles and implications for tissue injury healing

70%

Chai J., Tarnawski A. S.

Journal of Physiology and Pharmacology

2002

tom 53

nr 2

Serum response factor (SRF) is a transcription factor, which binds to a serum response element (SRE) associated with a variety of genes including immediate early genes such as c-fos, fosB, junB, egr-1 and –2, neuronal genes such as nurr1 and nur77 and muscle genes such as actins and myosins. By regulating expression of these genes, SRF controls cell growth and differentiation, neuronal transmission as well as muscle development and function. SRF can be activated by a variety of agents, including serum, lysophosphatidic acid (LPA), lipopolysaccharide (LPS), 12-O-tetradecanoylphorbol- 13-acetate (TPA), cytokines, tumor necrosis factor-. (TNF.... ), agents that increase intracellular Ca 2+, T-cell virus1 activator protein, hepatitis B virus activator proteins pX, activated oncogenes and protooncogenes as well as extracellular stimuli such as antioxidant and UV light. SRF itself is regulated by both cellular signal transduction pathways and interaction with other transcription factors e.g. Sp1, ATF6 and myogenic regulatory factors. Its biological function is best eluci-dated for myocardium. Specific cardiac SRF transgenesis demonstrated that overex-pression of SRF caused hypertrophic cardiomyopathy in mouse and the mouse died of heart failure within 6 months after birth. Other transgenic data suggested that suf-ficient SRF was needed for embryogenesis and early development. Since SRF is important regulator of numerous genes involved in cell growth and differentiation, including muscle and neural components, SRF may also play a crucial role in tissue injury and ulcer healing, e.g. healing of gastrointestinal ulcers.

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

2 Chai J.

1 Baatar D.

1 Moon W.

1 Tarnawski A.

1 Tarnawski A. S.

2 2002

Wyniki wyszukiwania

Expression of serum response factor in normal rat gastric mucosa

Serum response factor: discovery, biochemistry, biological roles and implications for tissue injury healing