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The results of recent studies indicate that obesity is associated with an increase in peroxidation processes. The aim of the present study was to assess the degree of oxidative stress in obese women and to evaluate the relationship between selected markers of oxidative stress and body mass index. Study population consisted of 43 women aged 21 to 66. Subjects were divided into two groups according to their body mass index (BMI): Overweight group (BMI < 30 kg/m2) and Obese group (BMI > 30 kg/m2). Venous blood samples were taken from each subject after an overnight fast and following parameters were assessed: plasma total antioxidant status (TAS), plasma concentrations of thiobarbituric acid reactive substances (TBARS), serum levels of antibodies against oxidized low density lipoproteins (oLAB), serum lipid profiles, serum glucose and insulin concentrations. Additionally, serum low density lipoprotein (LDL) cholesterol and insulin resistance indices were calculated. Serum triglyceride concentrations, insulin levels and insulin resistance indices were significantly higher in obese women in comparison with overweight ones. No significant differences in TBARS concentrations, TAS and oLAB levels were found between the two study groups. However, oLAB titres in Obese group were above the upper limit of the reference range for healthy adults. In both study groups significant correlations (p <0.01) between BMI and levels of triglycerides, insulin concentrations and insulin resistance indices were observed. Additionally, positive correlations (p < 0.05) between BMI and LDL-cholesterol and diastolic blood pressure as well as negative correlations (p < 0.05) between HDL-cholesterol and diastolic blood pressure were found in Obese group. In the overweight women, there were positive correlations between oLAB levels and triglyceride and insulin concentrations, between oLAB titres and insulin resistance indices and between oLAB levels and systolic and diastolic blood pressure (p < 0.01 for all correlations). There was also a negative correlation between oLAB titres and TAS (p < 0.05). The results of the present study confirm that obesity is associated with oxidative stress. Oxidative stress may be the link between obesity and atherosclerosis.
Obesity is a multivariate syndrome which can negatively affect whole body functioning. It is most common in highly developed countries, and in recent years a progressive increase in obesity occurrence is noticeable. The aim of the study was to assess serum lipid profile and metabolic syndrome occurrence among obese rural women from Lublin Region in Eastern Poland. The study was conducted in the Institute of Agricultural Medicine in Lublin (IAM). All subjects had a negative history of diseases and treatment that could affect serum lipid profile or glucose measurements. The inclusion criterion for the study group was overweight and obesity, defined as a body mass index above 25 (BMI>25) and living in a rural area. 44 women participated in the study. There were no women fulfilling the criteria or who had a history of incorrect fasting glucose (IFG) or incorrect glucose tolerance (IGT). In contrast, the prevalence of arterial hypertension (or treatment) was high - 53%. 22.7% women had normal serum TC values. The proportion of those with hyper-LDL-C was 38.6% and with hyper-TG - 18.2%. 20.5% of studied women had incorrect serum HDL-C levels, and in 15.9% hypo- HDL-C was accompanied by high serum TC levels. Analysis of correlation showed that serum TC was positively correlated with both LDL- and HDL-C. 55% of the studied obese or overweight women had at least 2 additional components of the metabolic syndrome.
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