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Involvement of some 5-HT receptors in methamphetamine-induced locomotor activity in mice

100%

Ginawi O. T., Al-Majed A. A., Al-Suwailem A. K., El-Hadiyah T. M. H.

Journal of Physiology and Pharmacology

2004

tom 55

nr 2

Effects of some selective 5-HT antagonists on methamphetamine-induced locomotor activity were investigated in male mice in order to study whether this effect of methamphetamine is selectively or at least partially, induced through stimulation of a specific serotonin receptor subtype. Methamphetamine (1.5mg/kg, IP) produced a significant increase in locomotor activity. Methamphetamine-induced hyperactivity by the above mentioned dose was signficantly antagonized by NAN-190 ( 5-HT1A antagonist) at a dose of 4 mg/kg, IP, methiothepin (5-HT1B/1D antagonist) at a dose of 0.1mg/kg, IP or mianserin ( 5-HT2C antagonist) at a dose of 8mg/kg, IP. On the other hand, methysergide ( 5-HT 2A/2B antagonist) at a dose of 1mg/kg, IP or ondansetron ( 5-HT3 antagonist) at a dose of 0.5mg/kg, IP potentiated the methamphetamine-induced hyperactivity. None of the above mentioned doses of 5-HT antagonists altered the spontaneous activity of mice when administered alone. The results of the present study indicate a possible role for serotonergic mechanisms, in addition to the catecholaminergic systems, in the locomotor stimulant activity of methamphetamine in mice. This role is possibly mediated through direct stimulation of some 5-HT receptor subtypes. Stimulation by methamphetamine of 5-HT 1A, 5-HT 1B/1D and/or 5-HT2C receptor subtypes may result in hyperactivity, whereas stimulation by methamphetamine of 5-HT 2A/2B and/or 5-HT3 receptor subtypes may result in decreased activity.

Propranolol modifies platelet serotonergic mechanisms in rats

100%

Zoltowski R., Pawlak R., Matys T., Pietraszek M., Buczko W.

Journal of Physiology and Pharmacology

2002

tom 53

nr 2

Though the mechanisms for the vascular actions of vasodilatory beta-blockers are mostly determined, some of their interactions with monoaminergic systems are not elucidated. Because there are evidences supporting a possible involvement of serotonin (5-HT) in the actions of beta-blockers, we studied the effect of propranolol on peripheral serotonergic mechanisms in normotensive and Goldblatt two-kidney - one clip (2K1C) hypertensive rats. In both groups of animals propranolol decreased systolic blood pressure, significantly increased whole blood serotonin concentration and at the same time it decreased platelet serotonin level. The uptake of the amine by platelets from hypertensive animals was lower than that of normotensive animals and it was decreased by propranolol only in the latter. In both groups propranolol inhibited potentiation of ADP - induced platelet aggregation by serotonin. In conclusion, this study provides evidence that propranolol modifies platelet serotonergic mechanisms in normotensive and renal hypertensive rats.

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

1 Al-Majed A. A.

1 Al-Suwailem A. K.

1 Buczko W.

1 El-Hadiyah T. M. H.

1 Ginawi O. T.

1 Matys T.

1 Pawlak R.

1 Pietraszek M.

1 Zoltowski R.

1 2004

1 2002

Wyniki wyszukiwania

Involvement of some 5-HT receptors in methamphetamine-induced locomotor activity in mice

Propranolol modifies platelet serotonergic mechanisms in rats