Wyniki wyszukiwania

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Role of afferent nerves and sensory peptides in the mediation of hepatic artery buffer response

100%

Biernat J., Pawlik W. W., Sendur R., Dembinski A., Brzozowski T., Konturek S. J.

Journal of Physiology and Pharmacology

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2005

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tom 56

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nr 1

Intrahepatic arteries are richly innervated by both adrenergic and sensory vanilloid-sensitive (capsaicin-sensitive) fibers. Stimulation of capsaicin sensitive fibers has been shown to dilate the intrahepatic vessels by both releasing sensory neuropeptides and by modulating the adrenergic tone. However the participation of capsaicin-sensitive fibers in the mediation of the hepatic artery buffer response (HABR) has not been investigated yet. To explore the involvement of sensory innervation and sensory neuropeptides in the HABR, the experiments were performed on capsaicin-denervated Wistar rats. In addition, we used selective CGRP and tachykinin receptor antagonists to test the participation of CGRP, substance P and NK-A in HABR in the rat. In anesthetized rats the hepatic artery blood flow (HABF), microcirculatory hepatic blood flow (HBF) and portal blood flow (PBF) were determined. The HABR was induced by partial occlusion of the portal vein and maintaining the PBF at 10% of its control preocclusive value. In the control HABR the hepatic artery blood flow increased by 89% (p< 0.005) whilst the HBF at the same time decreased by 32% (p< 0.005) in comparison to preocclusive HABF and HBF values. In sensory-denervated rats the resting HBF and PBF were increased by 23% (p< 0.05) and 34% (p< 0.05), respectively in comparison to the control HBF and PBF values. In this group the induction of the HABR increased the hepatic artery blood flow by only 55% (p< 0.05), whilst the HBF was reduced by 45% (p< 0.05). Pretreatment with CGRP 8-37 (CGRP receptor antagonist) and NK-1 but not NK-2 nor NK-3 receptor antagonists significantly reduced the HABF by 43% (p< 0.05) and 25 % (p< 0.05) as compared to the HABF value in the control HABR group. These findings support the hypothesis that the hepatic artery buffer response induced by reduction of the portal inflow to the liver by 90% is partially mediated by activation of capsaicin-sensitive sensory fibers in the liver, probably due to local tissue ischemia and hypoxia. The observed vasodilation in the vascular bed of the hepatic artery is due to stimulation of CGRP and NK-1 receptors.

2

Distribution of spinal sensory neurons supplying the adrenal gland in the pig

86%

Gonkowski S.

Folia Histochemica et Cytobiologica

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2002

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tom 40

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nr 4

3

Distribution of primary afferent neurons associated with the porcine inferior mesenteric ganglion [IMG]

86%

Bossowska A.

Folia Histochemica et Cytobiologica

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2002

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tom 40

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nr 4

4

Effect of econazole and benzydamine on sensory neurons in culture

72%

Mathivanan S., De la Torre Martinez R., Wolf C., Mangano G., Polenzani L., Milanese C., Ferrer-Montiel A.

Journal of Physiology and Pharmacology

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2016

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tom 67

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nr 6

5

Sensory neurons and liver protection

72%

Biernat J., Sendur R., Obuchowicz R., Jaworek J., Zejc-Bajsarowicz M., Pawlik W. W.

Journal of Physiology and Pharmacology. Supplement

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2001

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tom 52

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nr 2

6

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Myelectric bowel activity in ischemia-reperfusion damage. Role of sensory neurons

72%

Pawlik W. W., Thor P., Sendur R., Biernat J., Koziol R., Wasowicz P.

Journal of Physiology and Pharmacology

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1998

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tom 49

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nr 4

7

Effect of galanin on substance P- and vasoactive intestinal polypeptide-induced nociceptive trigemino-hypoglossal reflex in rats

72%

Zubrzycka M., Janecka A.

Journal of Physiology and Pharmacology

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2007

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tom 58

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nr 3

Substance P (SP), vasoactive intestinal polypeptide (VIP) and galanin (GAL), present in primary sensory neurons, are involved in transmission of nociceptive signaling from the peripheral to central nervous system. In this study we investigated the effect of GAL on SP-induced or VIP-induced evoked tongue jerks (ETJ) in response to noxious tooth pulp stimulation during perfusion of the cerebral ventricles with SP or VIP solutions. The experiments were carried out on rats under chloralose anesthesia. It was shown that both, SP and VIP, perfused through the cerebral ventricles enhanced the ETJ amplitude as compared with control, but the effect produced by SP was stronger. The intracerebroventricular perfusion of GAL 5 minutes before SP caused a dose-dependent inhibition of SP-induced ETJ, whereas GAL perfused through the cerebral ventricles 5 minutes before VIP did not reduce the excitatory effect of VIP on ETJ. These results indicate that the antinociceptive effect of GAL perfused through the cerebral ventricles, tested on the trigemino-hypoglossal reflex in rats, is specifically mediated by the SP-ergic system.

8

Surveillance of the gastrointestinal mucosa by sensory neurons

72%

Holzer P., Michl T., Danzer M., Jocic M., Schicho R., Lippe I. T.

Journal of Physiology and Pharmacology

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2001

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tom 52

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nr 4,1

A dense network of extrinsic and intrinsic sensory neurons supplies the gastrointestinal tract. Intrinsic sensory neurons provide the enteric nervous system with the kind of information that this brain of the gut requires for its autonomic control of digestion, whereas extrinsic afferents notify the brain about processes that are relevant to energy and fluid homeostasis and the sensation of discomfort and pain. The sensory repertoire of afferent neurons is extended by their responsiveness to mediators released from enteroendocrine and immune cells, which act like “taste buds” of the gut and serve as interface between the gastrointestinal lumen and the sensory nerve terminals in the lamina propria of the mucosa. Functional bowel disorders such as non-ulcer dyspepsia and irritable bowel syndrome are characterized by abdominal discomfort or pain in the absence of an identifiable organic cause. It is hypothesized with good reason that infection, inflammation or trauma causes sensory pathways to undergo profound phenotypic and functional alterations that outlast the acute insult. The pertinent changes involve an exaggerated sensitivity of the peripheral afferent nerve fibres as well as a distorted processing and representation of the incoming information in the brain. This concept identifies a number of receptors and ion channels that are selectively expressed by primary afferent neurons as important molecular targets at which to aim novel therapies for functional bowel disorders.

9

CGRP as mediator of circulatory and myoelectric changes observed in the small intestine subjected to ischemia and reperfusion [I-R]

72%

Sendur R., Biernat J., Obuchowicz R., Gajda M., Dembinski A., Warzecha Z., Pawlik W. W.

Journal of Physiology and Pharmacology. Supplement

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2001

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tom 52

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nr 2

10

Surveillance of the gastrointestinal mucosa by sensory neurons

72%

Holzer P.

Journal of Physiology and Pharmacology. Supplement

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2001

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tom 52

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nr 2

11

Distribution and neurochemical characterization of sensory dorsal root ganglia neurons supplying porcine urinary bladder

58%

Bossowska A., Crayton R., Radziszewski P., Kmiec Z., Majewski M.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

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nr 4

12

Esophagoprotective activity of angiotensin-(1-7) in experimental model of acute reflux esophagitis. Evidence of the role of nitric oxide, sensory nerves, hypoxia-inducible factor-1alpha and proinflammatory cytokines

58%

Pawlik M. W., Kwiecien S., Pajdo R., Ptak-Belowska A., Brzozowski B., Krzysiek-Maczka G., Strzalka M., Konturek S. J., Brzozowski T.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 6

13

Vanilloid receptor type 1-immunoreactive nerves in the rat urinary bladder and primary afferent neurones: the effects of age

58%

Saleh H. A. M.

Folia Morphologica

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2006

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tom 65

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nr 3

213-220

The vanilloid receptor (VR1) is a molecular integrator of various painful stimuli, including capsaicin, acid and high temperature. VR1 protein functions both as a receptor for capsaicin and a transducer of noxious thermal stimuli. In addition, VR1 is well characterised at the terminals of sensory nerves involved in the pain pathway. VR1 is also expressed in a capsaicin-sensitive and peptide-containing sub-population of primary sensory nerves. Indirect immunohistochemistry was used to examine the distribution of nerves immunoreactive (ir) for VR1 in the base of the urinary bladder and in the neurones of the lumbosacral dorsal root ganglia (L1-L2 and L6-S1) of young adult (3 months) and aged (24 months) male rats. Semi-quantitative estimations of nerve densities were assessed and quantitative studies were also used to examine the effects of age on the percentage of VR1-ir dorsal root ganglion neurones. The bladder base in young adults showed dense VR1-ir fibres within the urothelium and in the subepithelium and fibres ranging from sparse to moderate in number in the muscle coat. In comparison to the young animals, the aged rats showed sparse to moderate densities of VR1-ir nerves in the subepithelium and sparse fibres in the muscle layers. In the lumbosacral dorsal root ganglia the percentage of VR1-ir neuronal profiles showed a significant reduction from (mean ± SEM) 17.8 ± 2% in the young adult to 12 ± 1.6 in the aged rats. The present findings suggest that the effects of VR1 on bladder function (nociception and reflex micturition) are influenced by age and the reduction with age of VR1-ir neurones in the dorsal root ganglia could also have important implications for the micturition reflex.

14

Expression of mRNAs for PPT, CGRP, NF-200, and MAP-2 in cocultures of dissociated DRG neurons and skeletal muscle cells in administration of NGF or NT-3

58%

Zhang W., Li H., Xing Z., Yuan H., Kindy M. S., Li Z.

Folia Histochemica et Cytobiologica

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2012

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tom 50

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nr 2

15

Immediate plasticity of identifiable synapses in the land snails Helix lucorum

58%

Sokolov E., Palikhova T.

Acta Neurobiologiae Experimentalis

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1999

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tom 59

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nr 3

16

Role of capsaicin-sensitive neurons in the control of intestinal blood flow and oxygen uptake

58%

Gustaw P., Pawlik W. W., Jacobson E. D., Sendur R., Konturek S. J.

Journal of Physiology and Pharmacology

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1995

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tom 46

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nr 1

Ograniczanie wyników

Role of afferent nerves and sensory peptides in the mediation of hepatic artery buffer response

Distribution of spinal sensory neurons supplying the adrenal gland in the pig

Distribution of primary afferent neurons associated with the porcine inferior mesenteric ganglion [IMG]

Effect of econazole and benzydamine on sensory neurons in culture

Sensory neurons and liver protection

Myelectric bowel activity in ischemia-reperfusion damage. Role of sensory neurons

Effect of galanin on substance P- and vasoactive intestinal polypeptide-induced nociceptive trigemino-hypoglossal reflex in rats

Surveillance of the gastrointestinal mucosa by sensory neurons

CGRP as mediator of circulatory and myoelectric changes observed in the small intestine subjected to ischemia and reperfusion [I-R]

Surveillance of the gastrointestinal mucosa by sensory neurons

Distribution and neurochemical characterization of sensory dorsal root ganglia neurons supplying porcine urinary bladder

Esophagoprotective activity of angiotensin-(1-7) in experimental model of acute reflux esophagitis. Evidence of the role of nitric oxide, sensory nerves, hypoxia-inducible factor-1alpha and proinflammatory cytokines

Vanilloid receptor type 1-immunoreactive nerves in the rat urinary bladder and primary afferent neurones: the effects of age

Expression of mRNAs for PPT, CGRP, NF-200, and MAP-2 in cocultures of dissociated DRG neurons and skeletal muscle cells in administration of NGF or NT-3

Immediate plasticity of identifiable synapses in the land snails Helix lucorum

Role of capsaicin-sensitive neurons in the control of intestinal blood flow and oxygen uptake