Wyniki wyszukiwania

1

90th birthday of prof. Czesław Radzikowski

100%

Kusnierczyk P.

Archivum Immunologiae et Therapiae Experimentalis

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2019

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tom 67

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nr 5

2

A new fluorometric method for anti-Leishmania drug screening on axenic amastigotes

100%

Le P. P., Pagniez F., Abdala-Valencia H.

Acta Parasitologica

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2003

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tom 48

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nr 4

Primary screening of possible antileishmanial compounds is currently based either on the use of promastigotes, which are not the clinically relevant stage, or on the time-consuming intracellular amastigote test. With the aim of discovering new antileishmanial derivatives, a semi-automatized method using Leishmania axenic amastigotes and a fluorometric growth indicator (Alamar Blue®) was developed. This assay was evaluated in a comparative study of the susceptibility of promastigotes, axenic amastigotes and intracellular amastigotes of Leishmania mexicana with standard drugs used in antileishmanial therapy (meglumine antimoniate, amphotericin B, ketoconazole and allopurinol) and recently developed ether lipid compounds (edelfosine and miltefosine). The results showed that while inhibitory concentration 50s (IC₅₀s) of axenic and intracellular amastigotes were similar for all of the drugs tested, promastigotes and intracellular amastigotes IC₅₀s differed for three of the six compounds. In conclusion, this axenic amastigote model allowed us to combine the ease of in vitro drug screening on promastigote with the reliability of the IC₅₀ determination on intracellular amastigotes.

3

Evaluation of a rapid culture-based screening test for detection of methicillin resistant Staphylococcus aureus

84%

Fwity B., Lobmann R., Ambrosch A.

Polish Journal of Microbiology

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2011

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tom 60

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nr 3

The performance of a culture based assay, BacLite™ Rapid MRSA for the rapid detection (5 hours) of methicillin resistant Staphylococcus aureus (MRSA) from specimens (n = 377) obtained from nares, throat, wounds and perineum was investigated. Compared to culture based reference methods (chromogenic MRSA ID (bioMerieux)), selective enrichment broth, PBP2’ latex agglutination (Oxoid) and VITEK 2 identification (bioMerieux), an overall sensitivity of 71% with a 82% specificity and a negative predictive value (NPV) of 95% was provided. The Baclite™ test is rapid and easy to use and has the advantage of a culture-based detection method for MRSA.

4

The fragile X syndrome

84%

Szot M.

Folia Histochemica et Cytobiologica

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1997

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tom 35

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nr 3

5

Evaluation of physiological screening tests for breeding drought resistant triticale [x Triticosecale Wittmack]

67%

Grzesiak S., Grzesiak M. T., Filek W., Stabryla J.

Acta Physiologiae Plantarum

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2003

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tom 25

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nr 1

6

Zarządzanie jakością sensoryczną w przemysle piwowarskim. Cz.1. Wybór i selekcja kandydatów

51%

Choldrych M.

Przemysł Fermentacyjny i Owocowo-Warzywny

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2009

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tom 53

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nr 05

Ograniczanie wyników

1 Acta Parasitologica

1 Acta Physiologiae Plantarum

1 Archivum Immunologiae et Therapiae Experimentalis

1 Folia Histochemica et Cytobiologica

1 Polish Journal of Microbiology

1 Przemysł Fermentacyjny i Owocowo-Warzywny

1 Abdala-Valencia H.

1 Ambrosch A.

1 Choldrych M.

1 Filek W.

1 Fwity B.

1 Grzesiak M. T.

1 Grzesiak S.

1 Kusnierczyk P.

1 Le P. P.

1 Lobmann R.

1 Pagniez F.

1 Stabryla J.

1 Szot M.

1 2019

1 2011

1 2009