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The aim of this study was to compare the pharmacokinetics of paracetamol in calves of the BW (Black- -and-White) breed and cross-breed calves (BW × HF Holstein-Friesian) (50% HF). The effect of age on interbreed differences in the values of selected pharmacokinetic parameters of this model drug were also examined. The experiment was carried out on 20 healthy calves: 10 of BW breed and 10 cross-breed (50% HF). The paracetamol test was performed on calves aged 10, 20 and 40 days of life. The animals received this model drug per os at a dose of 5 mg/kg body weight. The concentration of paracetamol in plasma was determined by the spectrophotometric method. The pharmacokinetics of paracetamol were calculated through a non-compartmental method, using The TopFit computer software. The obtained results indicate that the age of calves had an influence on the values of pharmacokinetic parameters of paracetamol. We observed that most of the estimated pharmacokinetic parameters of this model drug differed significantly (P < 0.01) between 10, 20 and 40-day-old calves. It was stated that 10 and 20-day-old BW calves metabolized paracetamol faster compared to 50% HF calves, but the observed results differed insignificantly (P > 0.05). We also observed that 40-day-old 50% HF calves metabolized paracetamol at a significantly (P < 0.01) quicker rate compared to BW animals.
The aim of this study was to determine pig breed differences in semen parameters. A total of 1506 ejaculates were collected between 01.11.2005 and 31.04.2007 from 39 boars of WBP breed, PBZ breed and Pietrain-Duroc crossbreeds. All the ejaculates were taken and qualified for insemination at the Station of Sow Insemination in Świątki, the branch in Szczecinek, Poland. The following semen characteristics were examined: semen volume (after removing the gel plug) [ml], sperm concentration, live sperm count per ejaculate, percentage of live sperm with rapid or forward progression [%], sperm count in one insemination dose and the number of insemination doses received from a single ejaculate. The boar breed did not significantly influence the semen volume, sperm concentration, live sperm count, or the number of insemination doses from single ejaculates. Thus no clear effect of breed on semen characteristics has been determined.
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