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Apolipoproteins AI and B, and LpAI lipoprotein particles in normocholesterolemic and hypercholesterolemic subjects with documented coronary heart disease

100%

Jarosz A., Nowicka G.

Żywienie Człowieka i Metabolizm

2008

tom 35

nr 2

The relation between coronary heart disease risk and low density lipoprotein and high density lipoprotein cholesterol concentrations is well accepted. These parameters are widely used in coronary heart disease risk assessment. However, an evidence is accumulated that other lipoprotein related parameters may be useful in CHD risk prediction. The aim of the study was to assess differences in plasma levels of apolipoproteins AI and B, and apo AI containing lipoprotein subpopulations LpAI and LpAI/AII, between subjects with and without documented coronary heart disease but similar total cholesterol and LDL cholesterol levels. 233 subjects were studied. CHD patients were characterized by higher apo B levels than Control subjects with similar LDL cholesterol levels and these differences were visible in normocholesterolemic as well as in hypercholesterolemic subjects. Significantly lower levels of LpAI particles were noted in CHD patients. The drop in LpAI was significant even when no differences in HDL-cholesterol and apo AI concentration occurred. The presented data support the idea that measurements of apolipoprotein B and apo AI and especially LpAI particles levels may improve CHD risk assessment. These markers may be particularly useful in patients with no classical risk factors, patients with serum and LDL cholesterol levels in normal range.

Effect of daidzein, a soy isoflavone, on bone metabolism in Cd-treated ovariectomized rats

100%

Om A. S., Shim J. Y.

Acta Biochimica Polonica

2007

tom 54

nr 3

This study compared the ability of daidzein, a soy isoflavone, with that of 17 β-estradiol to prevent bone loss in cadmium (Cd)-exposed ovariectomized (OVX) rats during growth. Four week-old female Wistar rats were randomly assigned to five treatment groups of 9 rats each, either (1) sham-operated (SH); (2) OVX and placed on experimental diets (OVX); (3) OVX fed 50 ppm of CdCl2 (OVX-Cd); (4) OVX fed 50 ppm of CdCl2 and 10 µg of daidzein per kg of body mass (OVX-CD-D); or (5) OVX fed 50 ppm of CdCl2 and 10 µg of estrogen per kg of body mass (OVX-CD-E). All rats were given free access to AIN-76 modified diet and drinking water, with or without Cd, for 8 weeks. The OVX groups gained more (P < 0.05) body mass than the SH group. Femoral mass was increased by feeding daidzein and estradiol, whereas femoral length was not (P > 0.05) significantly different among groups. Femoral breaking force was not significantly different among groups, however, femoral BMD was significantly lower in OVX-Cd than in the SH and OVX groups. Morphologically proliferative cartilage and hypertrophic cells in femur showed normal distribution in OVX-Cd-D and OVX-Cd-E groups unlike those in OVX-Cd group. These findings suggest that Cd-OVX-induced osteopenia or osteoporosis probably results from an increase in bone turnover.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Żywienie Człowieka i Metabolizm

1 Jarosz A.

1 Nowicka G.

1 Om A. S.

1 Shim J. Y.

1 2008

1 2007

Wyniki wyszukiwania

Apolipoproteins AI and B, and LpAI lipoprotein particles in normocholesterolemic and hypercholesterolemic subjects with documented coronary heart disease

Effect of daidzein, a soy isoflavone, on bone metabolism in Cd-treated ovariectomized rats