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Czasopisma help

  1. 13 Acta Neurobiologiae Experimentalis

  2. 3 Acta Biologica Cracoviensia. Series Botanica. Supplement

  3. 3 Journal of Physiology and Pharmacology

  4. 2 Acta Biochimica Polonica

  5. 2 Cellular and Molecular Biology Letters

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Autorzy help

  1. 6 Zawilska J. B.

  2. 4 Nowak J. Z.

  3. 3 Rupik W.

  4. 2 Bembenek J.

  5. 2 Dejda A.

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  1. 1 2019

  2. 1 2018

  3. 1 2013

  4. 1 2011

  5. 2 2009

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1

Plasticity of the primate visual pathway following lesions in early and mature life

100%
Rosa M.
Acta Neurobiologiae Experimentalis
|
2019
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tom 79
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nr Suppl.1
In primates, visual function is dominated by the pathway that transmits visual information from the retina, via the lateral geniculate nucleus (LGN), to the primary visual cortex (V1). Although lesions of V1 lead to blindness, it is well documented that residual visual function can be retained within scotomas caused by V1 lesions, including (largely subconscious) abilities to locate some types of stimuli, and even to coarsely evaluate their characteristics (“blindsight”). These observations indicate that other thalamic projections can convey retinal inputs directly to the extrastriate cortex, bypassing V1. The exact characteristics of blindsight depend markedly on the age at which the lesion occurs. Patients and monkeys who sustained lesions early in life often show a greater range of abilities than those who had lesions in adulthood, including, in many cases, conscious perception. My laboratory has been investigating the types of physiological changes in subcortical and cortical areas which mediate such outcomes. For this purpose, we have developed a V1 lesion model based on the marmoset monkey, a small new world primate in which the anatomy and physiology of the visual pathways has been well characterised, and has accelerated development in comparison with macaque monkeys. In this talk, I will briefly review the characteristics of the marmoset as an advantageous animal model for studies of primate vision, including plasticity, describe recent findings on the physiological consequences of V1 lesions at different ages, and briefly report on current lines of work aimed at understanding the full circuitry of the marmoset visual cortex using a neuroinformatics approach.
2

hnRNP-R regulates the PMA-induced c-fos expression in retinal cells

100%
Huang J., Li S.-J., Chen X.-H., Han Y., Xu P.
Cellular and Molecular Biology Letters
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2008
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tom 13
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nr 2
303-311
This study focused on the function of hnRNP-R in the regulation of c-fos expression. We demonstrated that hnRNP-R accelerated the rise and decline phases of c-fos mRNAs and Fos proteins, allowing PMA to induce an augmented pulse response of c-fos expression. Then, we examined the role of the c-fos-derived AU-rich element (ARE) in hnRNP-R-regulated mRNA degradation. Studies with the ARE-GFP reporter gene showed that hnRNP-R significantly reduced the expression of GFP with an inserted ARE. Moreover, immunoprecipitation-RT-PCR analysis demonstrated that in R28 cells and rat retinal tissues, the c-fos mRNA was co-immunoprecipitated with hnRNP-R. These findings indicate that hnRNP-R regulates the c-fos expression in retinal cells, and that the ARE of c-fos mRNAs contributes to this regulation.
3

Accumulation of membranes and photoreceptor degeneration in mouse retina

100%
Kralj M., Pipan N.
Folia Morphologica
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1998
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tom 57
|
nr 4
4

p19 detected in the rat retina and pineal gland is a guanylyl cyclase-activating protein [GCAP]

100%
Dejda A., Matczak I., Gorczyca W. A.
Acta Biochimica Polonica
|
2002
|
tom 49
|
nr 4
The Ca2+ -dependent activation of retina-specific guanylyl cyclase (retGC) is medi­ated by guanylyl cyclase-activating proteins (GCAPs). Here we report for the first time detection of a 19 kDa protein (p19) with GCAP properties in extracts of rat retina and pineal gland. Both extracts stimulate synthesis of cGMP in rod outer segment (ROS) membranes at low (30 nM) but not at high (1 uM) concentrations of Ca2+ .AtlowCa2+ , immunoaffinity purified p19 activates guanylyl cyclase(s) in bovine ROS and rat reti­nal membranes. Moreover, p19 is recognized by antibodies against bovine GCAP1 and, similarly to other GCAPs, exhibits a Ca2+ -dependent electrophoretic mobility shift.
5

Morphometric study of the human embryonic retina

100%
Styszynski A., Wozniak W., Bruska M.
Folia Morphologica
|
1998
|
tom 57
|
nr 3
6

D2-dopamine receptor-mediated stimulation of inositol trisphosphate formation in chick retina

100%
Zawilska J. B., Krzemieniewska B., Orszulak-Michalak D., Nowak J. Z.
Acta Neurobiologiae Experimentalis
|
1996
|
tom 56
|
nr 4
7
Content available remote

Electrophysiology and pharmacology of the optic input to the rat intergeniculate leaflet in vitro

84%
Blasiak A., Blasiak T., Lewandowski M. H.
Journal of Physiology and Pharmacology
|
2009
|
tom 60
|
nr 1
171-180
The mammalian intergeniculate leaflet (IGL) of the thalamus is a neuronal element of the circadian timing system, which receives direct photic input from the retina. The purpose of this study was to analyze responses of rat IGL neurons in vitro to optic tract stimulation and to identify neurotransmitters released from the terminals of retinal ganglion cells in this structure. Following optic tract stimulation, most of the responding IGL cells were excited and only a minority of them were inhibited. Neurons showing the excitatory response were tested in the presence of AP-5, a selective antagonist of NMDA receptors. In most cases the responses were only partially inhibited by the presence of AP-5. Complete disappearance of excitatory responses was achieved by adding CNQX, an AMPA/kainate receptor-selective antagonist, to the standard incubation fluid. Inhibitory responses were blocked or considerably attenuated in the presence of bicuculline, a GABAA receptor antagonist, in the ACSF. This study demonstrated that glutamate is the main neurotransmitter mediating optic tract input to the IGL, acting mainly via non-NMDA ionotropic receptors. It was also shown that NMDA and GABAA receptors are involved in passing photic input to the IGL, albeit to a much lesser extent.
8

Expression of the pigment-dispersing factor (PDF) in developing retina of the grass snake Natrix natrix L. (Lepidosauria, Serpentes) embryos. Immunocytochemical studies

84%
Rupik W., Bembenek J.
Acta Biologica Cracoviensia. Series Botanica. Supplement
|
2008
|
tom 50
|
nr 1
9

Programmed cell death during retinal development in grass snake Natrix natrix L. (Lepidosauria, Serpentes) embryos

84%
Rupik W., Bembenek J.
Acta Biologica Cracoviensia. Series Botanica. Supplement
|
2008
|
tom 50
|
nr 1
10

Histological studies of the retina differentiation in grass snake Natrix natrix L. during embryogenesis

84%
Rupik W., Bajdak K., Krzeszowiak K.
Acta Biologica Cracoviensia. Series Botanica. Supplement
|
2008
|
tom 50
|
nr 1
11

Embryonic fissure and photoreceptor differentiation in the eye of adult Garra rufa Heckel 1843 [Cyprinidae, Teleostei]

84%
Al-Adhami M. A., Qar J., Al Khodur M.
Folia Biologica
|
2001
|
tom 49
|
nr 3-4
12
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

A synergistic interaction between histamine and vasoactive intestinal peptide [VIP] on cyclic AMP production in the chick pineal gland

84%
Nowak J. Z., Woldan-Tambor A., Kuba K., Zawilska J. B.
Journal of Physiology and Pharmacology
|
1998
|
tom 49
|
nr 3
13

Melatonin as a chemical indicator of environmental light-dark cycle

84%
Zawilska J. B.
Acta Neurobiologiae Experimentalis
|
1996
|
tom 56
|
nr 3
14

Photoreceptor guanylate cyclase variants: cGMP production under control

84%
Sokal I., Alekseev A., Palczewski K.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr 4
Changes in the Ca2+ concentration are thought to affect many processes, including signal transduction in a vast number of biological systems. However, only in few cases the molecular mechanisms by which Ca2+ mediates its action are as well understood as in phototransduction. In dark-adapted photoreceptor cells, the equilibrium level of cGMP is maintained by two opposing activities, such as phosphodiesterase (PDE) and guanylate cyclase (GC). Upon absorption of photons, rhodopsin-G-protein- mediated activation of PDE leads to a transient decrease in [cGMP] and subsequently to lowering of [Ca2+]. In turn, lower [Ca2+] increases net production of cGMP by stimulation of GC until dark conditions are re-established. This activation of GC is mediated by Ca2+-free forms of Ca2+-binding proteins termed GC-activating proteins (GCAPs). The last decade brought the molecular identification of GCs and GCAPs in the visual system. Recent efforts have been directed toward understanding the properties of GC at the physiological and structural levels. Here, we summarize the recent progress and present a list of topics of ongoing research.
15

P19 detected in the rat retina and pineal gland is a guanylyl cyclase activating protein [GCAP]

84%
Dejda A., Matczak I., Gorczyca W. A.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
16

Biphasic effect of the NMDA receptor antagonist MK-801 on the nocturnal NAT activity in chick retina

84%
Zawilska J. B., Rosiak J., Nowak J. Z.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 2
17

Comparative structural and functional study on the eye of freshwater teleosts: Clarias gariepinus, Malapterurus electricus, Anguilla anguilla and Oreochromis niloticus

67%
El-Mansi A. A., Fouda Y. A., Sabry D. A.
Folia Biologica
|
2018
|
tom 66
|
nr 2
18
Content available remote

Melatonin and its influence on immune system

67%
Szczepanik M.
Journal of Physiology and Pharmacology. Supplement
|
2007
|
tom 58
|
nr 6
19
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Viral causes of uveitis in cats

67%
Trbolova A.
Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii
|
2013
|
nr 2
20
Content available remote

Melatonin and aging: prospects for human treatment

67%
Bubenik G. A., Konturek S. J.
Journal of Physiology and Pharmacology
|
2011
|
tom 62
|
nr 1
Human life span, with or without modern medicine is around 85-95 years. All living creatures have their inner clock that measures their daily (circadian) and their seasonal (circannual) time. These time changes are mediated by the alteration of levels of melatonin, an evolutionary ancient hormone, which is produced in many body tissues, including the pineal gland, retina and the gastrointestinal tract (GIT). Light is blocking the production of melatonin in the pineal gland, darkness is stimulating it. So, the diurnal changes of light intensity of melatonin, provide a "daily clock" and the seasonal changes provide a "seasonal clock". Finally, the reduction of melatonin observed with aging, may indicate the presence of an "age clock". Melatonin is a strong antioxidant (often it is called scavenger of free radicals), which protects the body from the effects of noxious compounds. Therefore it was hypothesized that the reduction of melatonin levels with age contributes to the aging process. So far, the only remedy to extend the life span was a 40% reduction in caloric intake, which prolonged the life in mice, rats, dogs and monkeys by 30-50%. A large group of people imitate these experiments performed on animals, but the results of these experiments will not be known for several decades. How is being hungry prolonging the life span? There is a connection between caloric reduction and melatonin levels in GIT. Several experiments indicate that fasting in animals substantially increased their production of GIT melatonin. Therefore, instead of being permanently hungry, a prolongation of human life could be achieved by a replacement melatonin therapy. A daily intake of melatonin before bed time might achieve the same effect as fasting e.g. an increase of body melatonin levels, which will protect the individual from the ravages of old age. That includes Parkinson's disease and Alzheimer's disease. There is a large group of people taking melatonin daily who believe that melatonin is the "fountain of youth". Those are the subjects which will one day provide an experimental evidence of the efficacy of melatonin.
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