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Changes in the central respiratory rhythm following pharmacological blockade of the nucleus parabrachialis medialis in the rabbit

100%

Gromysz H.

Acta Neurobiologiae Experimentalis

1997

tom 57

nr 4

Involvement of nitric oxide in regulation of the medullary respiratory rhythm in neonatal rats

80%

Volgin D., Volgina A., Seredenko M.

Acta Neurobiologiae Experimentalis

2000

tom 60

nr 2

The NADPH-diaphorase (as a neuronal NO-synthase) reactivity in the medullary structures of the respiratory rhythm (RR) generator and the role of NO in the regulation of respiratory activity in the phrenic nerve of artificially superfused semi-isolated medulla-spinal cord preparations were investigated in newborn rats. NADPH-diaphorase positive neurons were found in all nuclei of both dorsal and ventral respiratory groups of neurons. The maximal density of stained cells was present within the rostral part of the ventrolateral medulla (VLM), in the region of the lateral paragigantocellular reticular nucleus. It was found that endogenous NO mediates the mechanism of tonic inhibitory control of the RR frequency located in the rostral VLM under normal and hypoxic conditions, and appears to be involved in generation of the basic RR by the more caudal structures of VLM. It was shown that NO biosynthesis mediates the effect of NMDA receptors activation on the RR.

Ograniczanie wyników

2 Acta Neurobiologiae Experimentalis

1 Gromysz H.

1 Seredenko M.

1 Volgin D.

1 Volgina A.

1 2000

1 1997

Wyniki wyszukiwania

Changes in the central respiratory rhythm following pharmacological blockade of the nucleus parabrachialis medialis in the rabbit

Involvement of nitric oxide in regulation of the medullary respiratory rhythm in neonatal rats