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Oxygen breathing and ventilation

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We investigated the ventilatory response to normobaric poikilocapnic hyperoxia in healthy subjects. The study was carried out in 26 subjects of the mean age 26 ±0.9 (SE) years, who breathed pure oxygen through a two-way valVE for 10 min. The subjects were in the sitting position with a mouthpiece and nose clip attached. Ventilatory flow was recorded using a pneumotachograph and minute ventilation was calculated from the tidal and frequency components. The SaO2 and alveolar CO2 tension were continuously monitored. Ten of the same subjects constituted a control group in which room air was substituted for oxygen and the tests repeated in the same way at another occasion. We found that oxygen breathing caused a transient 8.4% decline in ventilation, whose nadir was 1 min after the introduction of oxygen. Thereafter, ventilation increased significantly aboVE the baseline value and showed a further rising tendency toward the end of the test. We conclude that acute oxygen treatment is unlikely to haVE a major inhibitory effect on the carotid body-dependent ventilatory driVE in normal subjects. The determinants of the hyperoxic ventilatory stimulation remain to be established in further studies.
The aim of our 10-week-long experiment was to investigate the impact of training with additional dead space (DS) on spirometry and exercise respiration. Respiratory muscle training is applied to the development exercise capacity. Twenty cyclists were assigned to two groups: the experimental (E) and the control (C). All of them carried on with their initial training programme. During endurance trainings (twice per week) group E used additional DS (1000 cm3). Immediatelly before and after the experiment each participant was submitted to a spirometry and a continuous test. The spirometry test measured peak inspiratory (PIF) and expiratory (PEF) flows, forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). The continuous test measured tidal volume (TV), respiratory frequency (RF), along with inspiration and expiration times. Our experiment demonstrated TV increase and RF decrease in both groups. In addition, the TV value was significantly higher in group E than in C. The PIF value also increased significantly, PEF and FEV1 upward trend was observed in group E only. We concluded the additional respiratory DS used in the experimental group provoked an increase of airflow observed in the spirometry tests at rest and during intensive aerobic exercise.
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