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Influence of nonselective ETA-ETB receptor blockade on renal function in conscious rats: effects of renal denervation

100%
Girchev R., Markova P., Vuchidolova V.
Journal of Physiology and Pharmacology
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2004
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tom 55
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nr 2
The effects of nonselective ETA/ETB receptor blockade with intravenous bolus injection of bosentan (10 mg/kg) on renal excretory function and blood pressure were investigated in conscious, male, normotensive Wistar rats before and one week after bilateral renal denervation. Renal denervation was followed by an increase in urine flow rate from 4.54±0.38 to 5.72±0.36 µl/min.100 g b.w. (p<0.05) and a decrease in urine osmolality from 855.5±44.6 to 707.4±47.5 mosm/kg H2O (p<0.05). Bosentan administration in sham-operated rats resulted in decrease in urine flow rate from 4.54±0.38 to 3.49±0.34 µl/min.100 g b.w. (p<0.05), and increase in urine osmolality from 855.5±44.6 to 1075.0±76.1 mosm/kg H2O (p<0.05). Sodium excretion decreased from 226.9±20.0 to 155.1±11.0 nmol/min.100 g b.w. (p<0.01). Bosentan administration in renal denervated rats did not produce any changes in renal water or electrolyte excretions. Blood pressure, heart rate, clearance of Inulin or clearance of paraaminohippuric acid (PAH) did not change in sham-operated or renal denervated rats during nonselective ETA/ETB receptor blockade. Bosentan did not alter the baroreflex sensitivity or sympatho-vagal balance in sham-operated or renal denervated rats. In conclusion, an interaction between renal nerves and endothelins appears to be involved in the regulation of the renal excretory function.
2
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Rapid blood pressure increase after renal denervation in anaesthetized rats: interaction of oxidative stress and neuronal nitric oxide synthase

72%
Walkowska A., Vaneckova I., Sadowski J., Kompanowska-Jezierska E.
Journal of Physiology and Pharmacology
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2019
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tom 70
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nr 4
3
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Influence of renal denervation on renal effects of acute nitric oxide and ETA/ETB receptor inhibition in conscious normotensive rats

72%
Girchev R., Markova P., Vuchidolova V.
Journal of Physiology and Pharmacology
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2006
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tom 57
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nr 1
The role of renal nerves in the effects of concomitant NO synthase and non-selective ETA/ETB receptor inhibition on renal function was investigated in conscious normotensive Wistar rats. NO synthase inhibition alone (10 mg/kg b. w. i.v. L-NAME) in sham-operated rats with intact renal nerves induced an increase in systolic, diastolic and mean arterial pressure, urine flow rate, sodium, chloride and calcium excretion (p<0.05). The effect of L-NAME was markedly reduced by bosentan (10 mg/kg b.w. i.v.) and the values of urine flow rate, sodium, chloride and calcium excretions returned to control level (p<0.05). L-NAME administration one week after a bilateral renal denervation increased blood pressure to a similar extent as in sham-operated rats but decreased urine flow rate (p<0.05) and did not change electrolyte excretion. ETA/ETB receptor inhibition with bosentan during NO synthase inhibition in the renal denervated rats did not produce changes in urine flow rate or electrolyte excretion. NO synthase inhibition as well as concurrent NO synthase and ETA/ETB receptor inhibition did not change clearance of inulin or paraaminohippuric acid in sham-operated or renal denervated rats. These results indicate that renal sympathetic nerves play an important modulatory role in NO and endothelin induced effects on renal excretory function.
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