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1

Evidence for RNA recombination between distinct isolates of Pepino mosaic virus

100%
Hasiow-Jaroszewska B., Kuzniar A., Peters S. A., Leunissen J. A. M., Pospieszny H.
Acta Biochimica Polonica
|
2010
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tom 57
|
nr 3
Genetic recombination plays an important role in the evolution of virus genomes. In this study we analyzed publicly; available genomic sequences of Pepino mosaic virus (PepMV) for recombination events using several bioinformatics tools. The genome-wide analyses not only confirm the presence of previously found recombination events in PepMV but also provide the first evidence for double recombinant origin of the US2 isolate.
2

Changes in ion concentration in the air during the breathing process of a human being

100%
Suchanowski A., Wiszniewski A.
Polish Journal of Environmental Studies
|
1999
|
tom 08
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nr 4
This work discusses the influence of the human being on concebtrations and mobility of aeroions in the atmosphere. The performed investigations show that the concentration of anions decreases, in the vicinity of the human, on about 26 - 44%. This is the result of their recombination with charges existing in the human body. In the process of breathing there are no crucial changes to the concentration of ions of both polarisation, while there is a conciderable increase, by several hundred percent, in the number of large ions.
3

DNA topoisomerase II, intragenic recombination and chromosomal gene organization

100%
Glazkov M. V., Mechtcheriakova J. A.
Cellular and Molecular Biology Letters
|
2000
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tom 05
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nr 2
4

DNA topoisomerases as repair enzymes: Mechanism[s] of action and regulation by p53

84%
Larsen A. K., Gobert C., Gilbert C., Markovits J., Bojanowski K., Skladanowski A.
Acta Biochimica Polonica
|
1998
|
tom 45
|
nr 2
DNA topoisomerases regulate the organization of DNA and are important targets for many clinically used antineoplastic agents. In addition, DNA topoisomerases modulate the cellular sensitivity toward a number of DNA damaging agents. Increased topoisomerase II activities were shown to contribute to the resistance of both nitrogen mustard- and cisplatin-resistant cells. Similarly, cells with decreased topoisomerase II levels show increased sensitivity to cisplatin, carmustine, mitomycin C and nitrogen mustard. Recent studies propose that topoisomerases may be involved in damage recognition and DNA repair at several different levels including: 1) the initial recognition of DNA lesions; 2) DNA recombination; and 3) regulation of DNA structure. The stress-activated oncogene suppressor protein p53 can modulate the activity of at least three different human topoisomerases, either directly by molecular associations or by transcriptional regulation. Since DNA topoisomerases have considerable recombinase activities, inappropriately activated topoisomerases in tumor cells lacking functional p53 may contribute to the genetic instability of these cells.
5

V gene replacement in T and B lymphocytes: Illicit or regimented rearrangement?

84%
Golub R.
Archivum Immunologiae et Therapiae Experimentalis
|
2002
|
tom 50
|
nr 4
6

Single-stranded DNA-binding proteins [SSBs] - sources and applications in molecular biology

84%
Kur J., Olszewski M., Dlugolecka A., Filipkowski P.
Acta Biochimica Polonica
|
2005
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tom 52
|
nr 3
Single-stranded DNA-binding proteins (SSBs) play essential roles in DNA replication, recombination, and repair in bacteria, archaea and eukarya. The SSBs share a common core ssDNA-binding domain with a conserved OB (oligonucleotide/oligosaccharide binding) fold. This ssDNA-binding domain was presumably present in the common ancestor to all three major branches of life. In recent years, there has been an increasing interest in SSBs because they are useful for molecular biology methods and for analytical purposes. In this review, we concentrate on recent advances in the discovery of new sources of SSBs as well as certain aspects of their applications in analytical sciences.
7

Bacterial DNA repair genes and their eukaryotic homologues: 5. The role of recombination in DNA repair and genome stability

84%
Nowosielska A.
Acta Biochimica Polonica
|
2007
|
tom 54
|
nr 3
Recombinational repair is a well conserved DNA repair mechanism present in all living organisms. Repair by homologous recombination is generally accurate as it uses undamaged homologous DNA molecule as a repair template. In Escherichia coli homologous recombination repairs both the double-strand breaks and single-strand gaps in DNA. DNA double-strand breaks (DSB) can be induced upon exposure to exogenous sources such as ionizing radiation or endogenous DNA-damaging agents including reactive oxygen species (ROS) as well as during natural biological processes like conjugation. However, the bulk of double strand breaks are formed during replication fork collapse encountering an unrepaired single strand gap in DNA. Under such circumstances DNA replication on the damaged template can be resumed only if supported by homologous recombination. This functional cooperation of homologous recombination with replication machinery enables successful completion of genome duplication and faithful transmission of genetic material to a daughter cell. In eukaryotes, homologous recombination is also involved in essential biological processes such as preservation of genome integrity, DNA damage checkpoint activation, DNA damage repair, DNA replication, mating type switching, transposition, immune system development and meiosis. When unregulated, recombination can lead to genome instability and carcinogenesis.
8

Sequence diversity of MHC class II DRB genes in the bank vole Myodes glareolus

84%
Babik W., Radwan J.
Acta Theriologica
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2007
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tom 52
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nr 3
In recent years, the bank voleMyodes glareolus (Schreber, 1780) has emerged as a model system for parasitological, behavioural and ecological studies and seems ideally suited to address questions concerning the importance of MHC variation at individual and population levels. Here, we provide the first extensive survey of sequence variation in the MHC class II DRB genes in this species. Among 34 analysed voles we found 15 unique sequences, representing most likely two loci, at least one of them expressed. Despite very high overall sequence divergence, particularly in the Antigen Binding Sites (ABS), we detected signatures of positive selection that has been acting on DRB in the bank vole. Phylogenetic analysis demonstrated that the bank vole DRB alleles do not form a monophyletic group but are intermingled with other rodent alleles that is consistent with long-term persistence of ancient allelic lineages maintained through balancing selection. Our sequence data will forward the design of efficient genotyping methods, which will permit testing hypotheses pertaining to the ecological causes and consequences of MHC variation in the bank vole.
9

Genetic constitution of parthenogenetic form of Polydrusus inustus [Coleoptera: Curculionidae] - hints of hybrid origin and recombinations

67%
Kajtoch L., Lachowska-Cierlik D.
Folia Biologica
|
2009
|
tom 57
|
nr 3-4
149-156
10

Sp100 interacts with phage ΦC31 integrase to inhibit its recombination activity

67%
Lin Y., Li Z., Wang J., Xu G., Shen Q., Tian L., Xue J., Chen J.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 1
 Phage ΦC31 integrase is a potential vector for the insertion of therapeutic genes into specific sites in the human genome. To understand the mechanism involved in ΦC31 integrase-mediated recombination, it is important to understand the interaction between the integrase and cellular proteins. Using a yeast two-hybrid system with pLexA-ΦC31 integrase as bait, we screened a pB42AD human fetal brain cDNA library for potential interacting cellular proteins. From the 106 independent clones that were screened, 11 potential interacting clones were isolated, of which one encoded C-terminal fragment of Sp100. The interaction between Sp100 and ΦC31 integrase was further confirmed by yeast mating and co-immunoprecipitation assays. The hybridization between a ΦC31 integrase peptide array and an HEK293 cell extract revealed that residues 81RILN84 in the N-terminus of ΦC31 integrase are responsible for the interaction with Sp100. Knocking down endogenous Sp100 with Sp100-specific siRNA increased ΦC31 integrase-mediated recombination but did not impact reporter gene expression. Therefore, endogenous Sp100 may interact with ΦC31 integrase and inhibit the efficiency of ΦC31 integrase-mediated recombination.
11

The dynamic nature of plant mitochondrial genome organization

59%
Janska H., Woloszynska M.
Acta Biochimica Polonica
|
1997
|
tom 44
|
nr 2
The characteristic features of higher plant mitochondrial genomes: size, structure, recombination activity and evolutionary dynamics, are reviewed with the emphasis on the mitochondrial DNA (mtDNA) of Phaseolus vulgaris. Among all examined eukaryotic organisms, higher plants were found to contain the largest and most complex mitochondrial genomes. The plant mtDNA structure in vivo and mechanisms of evolution are controversial. We present the currently accepted models and how these models correspond to mitochondrial genomes of several common bean lines.
12

Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter- like products

51%
Staniewski B., Kisza J., Hadal A., Juskiewicz M.
Acta Academiae Agriculturae ac Technicae Olstenensis. Technologia Alimentorum
|
1994
|
nr 26
3-13
13

Some attributes of emulsifier varied- recombined oil- in- water emulsions [ cream ] developed by two- stage homogenization

51%
Kisza J., Juskiewicz M., Hadal A., Staniewski B.
Acta Academiae Agriculturae ac Technicae Olstenensis. Technologia Alimentorum
|
1994
|
nr 26
15-27
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