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1

Using plasma dopamine beta-hydroxylase activity and its interrelations with bioelement content to predict depression in the rat model

100%
Grabowska M., Schlegel-Zawadzka M., Nowak G., Papp M.
Acta Biologica Cracoviensia. Series Zoologia
|
2002
|
tom 44
2

Inulin supplementation in rat model of pouchitis

84%
Drzymala-Czyz S., Banasiewicz T., Tubacka M., Majewski P., Biczysko M., Koscinski T., Drews M., Walkowiak J.
Acta Biochimica Polonica
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2011
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tom 58
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nr 3
Available data indicates potential effectiveness of prebiotic therapy in alleviating inflammation and prolonging the remission in inflammatory bowel disease. Documented successes of such therapies were the basis for this study. So far, there is no data related to the effectiveness of inulin application in symptomatic or severe pouchitis in humans or in animal model. The aim of the study was to determine the effect of inulin supplementation on the expression of intestinal inflammation and feeding efficiency in rats with induced pouchitis. Twenty-four Wistar rats were operated. After induction of pouchitis animals were randomly divided into control and supplementation groups receiving, respectively, semi-synthetic diet with or without inulin (in a lower (LD) or higher (HD) dose: 2.5 % or 5 % of total dietary content of mass) for a period of 6 weeks. Selected nutritional parameters were assessed throughout the study. Histopathological and immunohistochemical analysis of pouch mucosa specimens was also performed. The energy intake, weight gain, feeding efficiency, quality of stools were comparable in all studied groups. The intensity of inflammation (Moskovitz scale) and adaptive changes (Laumonier scale) did not differ between compared groups. The tissue expression of pro- and anti-inflammatory interleukins (IL-1α, IL-6, IL-10 and IL-12) was not different either. Inulin supplementation does not improve the quality of stools or the expression of intestinal inflammation in rats with induced pouchitis. It has no impact on the intensity of pouch adaptation or on feeding efficiency.
3

A note on the development of a rat model for cholesterol and lipoprotein metabolism - short report

84%
Pisulewski P. M., Kopec A., Cieslik E.
Polish Journal of Food and Nutrition Sciences
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2002
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tom 11/52
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nr 4
Twenty-four growing male rats of Wistar strain, weighing initially 120±3.5 g were randomly divided into four groups of six animals each and fed four different diets for 14 days: I - control diet (AIN-93G with soybean oil as a source of fat: 7 g/100 g), II - high-cholesterol diet (AIN-93G with soybean oil as a source of fat: 7 g/100 g + 1 g/100 g cholesterol), III - high-cholesterol diet (AIN-93G with lard as a source of fat: 7 g/100 g + + 1 g/100 g cholesterol), and IV - high-cholesterol diet (AIN-93G with lard as a source of fat: 7 g/100 g lard + 1 g/100 g cholesterol + 0.5 g/100 g cholic acid). On the day 14, the rats were anaesthetized and killed by withdrawing blood from the heart to obtain serum samples. The most striking increases (PcO.Ol) in the serum total and LDL+VLDL cholesterol were induced by the diet containing lard and supplemented with cholesterol + cholic acid (Group IV). Conversely, feeding the above diet to rats produced minimum (P<0.01) concentrations of the serum HDL cholesterol. It is concluded that the present animal model may be useful for evaluating the role of dietary factors in the development or regression of hypercholesterolemia.
4

Neuroprotective effects of dehydroepiandrosterone (DHEA) in rat model of Alzheimer's disease

67%
Aly H. F., Metwally F. M., Ahmed H. H.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 4
 The current study was undertaken to elucidate a possible neuroprotective role of dehydroepiandrosterone (DHEA) against the development of Alzheimer's disease in experimental rat model. Alzheimer's disease was produced in young female ovariectomized rats by intraperitoneal administration of AlCl3 (4.2 mg/kg body weight) daily for 12 weeks. Half of these animals also received orally DHEA (250 mg/kg body weight, three times weekly) for 18 weeks. Control groups of animals received either DHAE alone, or no DHEA, or were not ovariectomized. After such treatment the animals were analyzed for oxidative stress biomarkers such as hydrogen peroxide, nitric oxide and malondialdehyde, total antioxidant capacity, reduced glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase activities, antiapoptotic marker Bcl-2 and brain derived neurotrophic factor. Also brain cholinergic markers (acetylcholinesterase and acetylcholine) were determined. The results revealed significant increase in oxidative stress parameters associated with significant decrease in the antioxidant enzyme activities in Al-intoxicated ovariectomized rats. Significant depletion in brain Bcl-2 and brain-derived neurotrophic factor levels were also detected. Moreover, significant elevations in brain acetylcholinesterase activity accompanied with significant reduction in acetylcholine level were recorded. Significant amelioration in all investigated parameters was detected as a result of treatment of Al-intoxicated ovariectomized rats with DHEA. These results were confirmed by histological examination of brain sections. These results clearly indicate a neuroprotective effect of DHEA against Alzheimer's disease.
5

The apparent impact of gestational magnesium (Mg) deficiency on the sudden infant death syndrome (SIDS)

67%
Caddell J. L.
Journal of Elementology
|
2002
|
tom 07
|
nr 3
p.291-239,fig.,ref.
6

Contralateral somatosensory neglect in unrestrained rats after lesion of the parietal cortex of the left hemisphere

67%
Holm S., Mogensen J.
Acta Neurobiologiae Experimentalis
|
1993
|
tom 53
|
nr 4
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