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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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A moderate dose of cycloheximide does not prevent the febrile response to endotoxin but interfere with induction of pyrogenic tolerance in rabbit

100%
Kozak W., Soszynski D., Wachulec M., Szewczenko M., Bodurka M.
Journal of Physiology and Pharmacology
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1992
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tom 43
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nr 2
The purpose of the present study was to examine the effect of cycloheximide (Cx) - inhibitor of protein synthesis, on the development of pyrogenic tolerance to LPS. It has been observed that Cx at a dose of 1 mg/kg given intravenously 1 h prior to LPS did not prevent fever response, however it modified the induction of pyrogenic tolerance. It was manifested in existence of the second phase of fever after the following administrations of LPS into rabbits pretreated with Cx. In control group of rabbits the induction of pyrogenic tolerance was accompanied with decaying of the second peak of fever visible as early as the second dose of LPS.
2

Changes of internal temperature and locomotor activity under the conditions of endotoxin fever, pyrogenic tolerance and its suppression in pigeons

67%
Dudek K., Bednarek D., Soszynski D., Kozlowska M.
Medycyna Weterynaryjna
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2011
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tom 67
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nr 01
The aim of the study was to investigate changes of internal temperature and locomotor activity of birds in conditions of endotoxin fever, pyrogenic tolerance and its suppression. The experiment was performed in pigeons (n = 12). On the first day of the experiment a state of endotoxin fever was evoked. The pigeons were categorized into two groups: experimental and control. The first group of the animals (n = 8) received Escherichia coli LPS intravenously once at the dose of 10 µg/kg b.w. whereas the control pigeons (n = 4) were administered in the apyrogenic saline intravenously once at the dose of 1 ml/kg b.w. On the second and third day of the experiment the state of pyrogenic tolerance was induced in the pigeons and their internal temperature and locomotor activity were investigated. To this end the experimental group of birds received E. coli LPS intravenously twice at 24 h intervals at a dose of 10 µg/kg b.w. Conversely, the control pigeons were twice treated with saline (1 ml/kg b.w.). On the fourth day of the study an attempt of pyrogenic tolerance suppression in the pigeons was carried out. The experimental birds with the stable state of pyrogenic tolerance were then categorized into two subgroups. The first subgroup (n = 4) received Salmonella Abortusequi LPS intravenously at the dose of 10 µg/kg b.w., whereas the second one (n = 4) - E. coli LPS at a double amount of the pyrogen (20 µg/kg b.w.). The control pigeons were administered S. Abortusequi LPS in an analogical dose as the first experimental subgroup. Results of the study indicated the occurrence of endotoxin fever and depression of locomotor activity of the pigeons in response to the first injection of E. coli LPS. The third administration of the pyrogen stabilized the state of pyrogenic tolerance, manifested by the reduction of the increased internal temperature and the stimulation of pigeon locomotor activity. Whereas in the state of stable pyrogenic tolerance in pigeons the intravenous injection of the other exogenous pyrogen, i.e. S. Abortusequi LPS, and also the double dose of E. coli pyrogen caused the suppression of the tolerance and the restoration of endotoxin fever in the birds.
3
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Cellular immune response of pigeons in the conditions of endotoxin fever and pyrogenic tolerance

67%
Dudek K., Bednarek D.
Polish Journal of Veterinary Sciences
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2011
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tom 14
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nr 1
The aim of this study was to investigate changes in selected parameters of cellular immune response in the conditions of endotoxin fever and pyrogenic tolerance in pigeons. On the first day of observation the experimental birds (n=18) were intravenously injected with Escherichia coli LPS at a dose of 10 μg/kg b.w., while the control animals (n=6) received apyrogenic physiological saline also in the form of injection. On the second and the third day of the experiment LPS was injected additionally at 24 h intervals. Four and a half hours after the saline and pyrogen administration blood samples were collected from the control and experimental pigeons. The following immunological assays were performed: WBC, leucogram and immunophenotyping of lymphocyte subsets in peripheral blood, i.e. CD 3+ (T lymphocytes), CD 4+ (T helper lymphocytes) and CD 8+ (T suppressor/ cytotoxic lymphocytes) cells. In the conditions of endotoxin fever (i.e. after the first LPS injection) leucopenia, monocytopenia, heterophilia and eosinophilia were observed. Additionally, the immunophenotyping of peripheral blood lymphocytes indicated an increase in percentage of CD 3+, CD 4+ and CD 8+ cells in response to the single injection of LPS. In contrast, the consecutive injections of LPS, which created a pyrogenic tolerance effect, caused a decrease in WBC value, heteropenia, eosinopenia and lymphocytosis. Moreover, during this state an increase in percentage of CD 3+ and CD 8+ cells was demonstrated in contrast to the percentage of CD 4+ lymphocytes. The general tendencies in cellular immune response of the affected pigeons in the conditions of endotoxin fever and pyrogenic tolerance aim at activation of defence mechanisms against LPS for its prompt elimination from the animal’s organism.
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