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1

Susceptibility to various coccidiostats in the murine coccidian parasite Eimeria krijgsmanni

100%
Inoue K., Tsujio M., Matsubayashi M., Inoue R., Hatai H., Andoh M., Abe K., Matsui T., Matsuo T.
Acta Parasitologica
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2019
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tom 64
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nr 2
2

Pravastatin and simvastatin pretreatment in combination with pyrimethamine and sulfadiazine reduces infection process of Toxoplasma gondii tachyzoites (RH strain) in HeLa cells

100%
da Silva Sanfelice R. A., da Silva S. S., Bosqui L. R., Machado L. F., Miranda-Sapla M. M., Panagio L. A., Navarro I. T., Conchon-Costa I., Pavanelli W. R., Almeida R. S., Costa I. N.
Acta Parasitologica
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2019
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tom 64
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nr 3
3

Frequencies of dhfr/dhps multiple mutations and Plasmodium falciparum submicroscopic gametocyte carriage in Gabonese pregnant women following IPTp-SP implementation

84%
Bouyou-Akotet M. K., Tshibola M.-L., Mawili-Mboumba D. P., Nzong J., Bahamontes-Rosa N., Tsoumbou-Bakana G., Kombila M.
Acta Parasitologica
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2015
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tom 60
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nr 2
4
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Monitoring of plasma concentration of pyrimethamine (PYR) in infants with congenital Toxoplasma gondii infection – own observations

84%
Lipka B., Milewska-Bobula B., Filipek M.
Wiadomości Parazytologiczne
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2011
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tom 57
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nr 2
The study objective was to determine plasma concentration of pyrimethamine in 24 infants aged 1–5 months, treated for congenital toxoplasmosis. Pyrimethamine was used in a single daily dose at an amount of 0.35–0.98 mg/kg daily, with sulfadiazine (50–100 mg/kg/day) in divided doses 2–3 times a day, and folinic acid given twice a week (7.5 mg). This regimen was continued for 2–6 months, then Fansidar® was administered. Pyrimethamine concentration in plasma was measured using high-performance liquid chromatography method (HPLC). A total of 70 tests were performed. Concentration of pyrimethamine ranged from 0.01 to 1.2 μg/ml. In 14 children (58 tests) the concentration of pyrimethamine achieved therapeutic value. In 7 patients (8 tests) the concentration was below therapeutic level, and in 3 patients (4 tests) above therapeutic level. In 11/24 (46%) children transient moderate neutropenia was observed. Modification of therapy was necessary in 12 patients. Monitoring of pyrimethamine concentration in plasma improves safety and effectiveness of the therapy and is useful in obtaining correct individual dose of the drug. Neutropenia is the most common side-effect of pyrimethamine observed even when using the recommended dose.
5

Detection of molecular markers for chloroquine and pyrimethamine-sulfadoxine resistance in imported cases of Plasmodium falciparum malaria in Poland

84%
Myjak P., Nahorski W., Szostakowska B., Zarnowska-Prymek H., Pietkiewicz H.
Acta Parasitologica
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2007
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tom 52
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nr 3
The identified mutations in the pfcrt, dhfr and dhps genes of Plasmodium falciparum show a very high correlation with resistance to chloroquine, pyrimethamine and sulfadoxine, the drugs that are still used as malaria chemoprophylaxis or treatment. We undertook a molecular screening of 82 Polish P. falciparum isolates, mainly imported from different countries of sub-Saharan Africa to assess their molecular drug-resistance profiles. Only 4 isolates showed no mutations in the three analyzed gene fragments. In the remaining isolates from one to six mutations in one or more examined genes were found. Different mutations in the pfcrt, dhfr and dhps genes were found in ca. 76%, 80% and 70% of P. falciparum isolates, respectively. About forty our patients used chloroquine or pyrimethamine + sulfadoxine as malaria chemoprophylaxis and/or antimalarial treatment, but without success. In all but 5 of the P. falciparum isolates obtained from these persons, mutations associated to resistance of the parasite to chloroquine and the antifolate drugs were found.
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