Wyniki wyszukiwania

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Changes of pH in Petunia hybrida [Hort.] styles induced by pollination and influence of proton pump and ion channels on its regulation

100%

Filek M., Wedzony M., Bednarska E.

Acta Physiologiae Plantarum

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2003

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tom 25

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nr 1

2

Targeting the fungal plasma membrane proton pump

84%

Monk B. C., Mason A. B., Kardos T. B., Perlin D. S.

Acta Biochimica Polonica

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1995

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tom 42

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nr 4

The need for new mechanistic classes of broad spectrum antifungal agents has prompted development of the membrane sector and ectodomain of the plasma membrane proton pumping ATPase as an antifungal target. The fungal proton pump is a highly abundant, essential enzyme in Saccharomyces cerevisiae. It belongs to the family of P-type ATPases, a class of enzymes that includes the Na+,K+-ATPase and the gastric H+,K+-ATPase. These enzymes are cell surface therapeutic targets for the cardiac glycosides and several anti-ulcer drugs, respectively. The effects of acid- -activated omeprazole show that extensive inhibition of the S. cerevisiae ATPase is fungicidal. Fungal proton pumps possess elements within their transmembrane loops that distinguish them from other P-type ATPases. These loops, such as the conformationally sensitive transmembrane loop 1+2, can attenuate the activity of the enzyme. Expression in S. cerevisiae of fully functional chimeric ATPases that contain a foreign target comprising transmembrane loops 1+2 and/or 3+4 from the fungal pathogen Candida albicans suggests that these loops operate as a domain. The chimera containing C. albicans transmembrane loops 1+2 and 3+4 provides a prototype for mutational analysis of the target region and the screening of inhibitors directed against opportunistic fungal pathogens. Panels of mutants with modified ATPase regulation or with altered cell surface cysteine residues are also described. Information about the ATPase membrane sector and ectodomain has been integrated into a model of this region.

3

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Functional and structural changes of isolated rat parietal cells during membrane potential modulation

84%

Ostrowski J., Jarosz D., Zych W., Wojciechowski K.

Journal of Physiology and Pharmacology

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1994

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tom 45

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nr 3

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One week treatment with omeprazole, clarithromycin and tinidazole or lansoprazole, amoxicillin and metronidazole for cure of Helicobacter pylori infection in duodenal ulcer patients

59%

Sito E., Konturek P. C., Bielanski W., Kwiecien N., Konturek S. J., Baniukiewicz A., Jedynak M., Gabryelewicz A., Hahn E. G.

Journal of Physiology and Pharmacology

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1996

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tom 47

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nr 1

5

Działanie fitohormonów na potencjał membranowy, przyrost świeżej masy i pompę protonową w komórkach koleoptyli Triticum vulgare L.

51%

Stolarek J., Zientara M.

Acta Biologica Silesiana

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1991

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tom 17

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

1 Acta Biochimica Polonica

1 Acta Biologica Silesiana

1 Acta Physiologiae Plantarum

1 Baniukiewicz A.

1 Bednarska E.

1 Bielanski W.

1 Filek M.

1 Gabryelewicz A.

1 Hahn E. G.

1 Jarosz D.

1 Jedynak M.

1 Kardos T. B.

1 Konturek P. C.

1 Konturek S. J.

1 Kwiecien N.

1 Mason A. B.

1 Monk B. C.

1 Ostrowski J.

1 Perlin D. S.

1 Sito E.

1 Stolarek J.

1 Wedzony M.

1 Wojciechowski K.

1 Zientara M.

1 Zych W.

1 2003

1 1996

1 1995

1 1994

1 1991

Changes of pH in Petunia hybrida [Hort.] styles induced by pollination and influence of proton pump and ion channels on its regulation

Targeting the fungal plasma membrane proton pump

Functional and structural changes of isolated rat parietal cells during membrane potential modulation

One week treatment with omeprazole, clarithromycin and tinidazole or lansoprazole, amoxicillin and metronidazole for cure of Helicobacter pylori infection in duodenal ulcer patients

Działanie fitohormonów na potencjał membranowy, przyrost świeżej masy i pompę protonową w komórkach koleoptyli Triticum vulgare L.