The distribution of Mg and Ca contents in sera was assessed after the administration of magnesium and magnesium-calcium preparations in 28 normal cows. The experiment was carried out on four groups of animals. The following were evaluated: 25 per cent magnesium sulfu- ricum, 25 per cent magnesium sulfuricum combined with 25 per cent calcium borogluconatum, 20 per cent magnesium gluconicum and Calcigluc, ie. magnesium-calcium compound containing chlorides and gluconates. The above preparations, depending on the mineral contents, were given in the form of intravenous infusions, subcutaneous or intramuscular injections at the rate commonly used or recommended. For the purposes of the examination, the samples of blood were taken before administering the preparations; at 15 min; then at 1, 2, 4, 8, 12, 24 and 48 hours. Comparative magnesium and calcic preparations curves indicated that magnesium gluconicum was more useful than magnesium sulfate. After the magnesium gluconicum infusion an increase of Mg level was observed which persisted in the blood for 12 hours. A similar prolonged effect could be achieved by means of magnesium sulfate given simultaneously i.v. and i.m. Recommended doses of 20% magnesium gluconate (0,5 ml per 1 kg of body weight) were relatively small and could be even doubled without any direct side effect. The addition of calcium sulfate to magnesium negatively influenced increase of Mg concentration in the serum, which makes the drug safer and enables the use of high doses, though we do not know much about its final biological effect.
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