The aim of this study was to evaluate Eprinex Pour-On against gastro-intestinal nematodes in naturally infected goats. Two groups, each including adults and one-year old goats were treated with standard bovine dose and double dose rate. The prevalence and intensity of gastro-intestinal nematodes infection was determined based on faecal samples examination on the day of treatment (day 0) and 7,14,34, 56,90 and 125 days after the treatment. The low efficacy of the recommended bovine dose rate was stated within the first two weeks after the treatment (59.5% and 89.9% in adults and yearlings, respectively). In double dosed animals, the efficacy was 97.6% and 88.5% on the 56th day after dosing in adults and young, respectively. The results of the study demonstrate the high and persistent efficacy of Eprinex against gastro-intestinal nematodes in goats in a double bovine dose rate. They also indicate the dose is highly effective against the mucosal stages of goats’ nematodes.