Wyniki wyszukiwania

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Expression of estrogen receptors in the pelvic floor of pre- and post-menopausal women presenting pelvic organ prolapse

100%

Zbucka-Kretowska M., Marcus-Braun N., Eboue C., Abeguile G., Wolczynski S., Kottler M. L., Von Theobald P.

Folia Histochemica et Cytobiologica

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2011

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tom 49

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nr 3

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Evaluation of urinary 6-hydroxymelatonin sulphate excretion in women at different age with irritable bowel syndrome

80%

Wisniewska-Jarosinska M., Chojnacki J., Konturek S., Brzozowski T., Smigielski J., Chojnacki C.

Journal of Physiology and Pharmacology

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2010

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tom 61

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nr 3

295-300

Melatonin (MT) exerts a beneficial action in the treatment of many diseases, among them also in irritable bowel syndrome (IBS). Its secretion decreases with age, particularly, in the postmenopausal period in women. It has not been determined whether these changes can have an impact on the clinical picture of IBS. The study aimed at evaluating the urinary excretion of the main MT metabolite - 6-hydroxymelatonin sulphate (6-HMS) in women at different age with IBS. The investigations were carried out in five groups of 30 women each. Group Ia (the controls) – premenopausal healthy women (20-39 years), group Ib (the controls) – postmenopausal healthy women (46-66 years), group II – women with constipation predominant IBS (IBS-C; 19-42 years), group III – women with diarrhoea predominant IBS (IBS-D; 20-39 years), group IV- women with IBS-C (49-68 years), group V – women with IBS-D (48-69 years). The diagnosis of IBS was based on the Rome III Criteria after excluding other diseases. On the day of the study the patients remained on the same liquid diet (Nutridrink – 3x400 ml) and 1500 ml of still mineral water. 6-HMS concentration in urine was measured by ELISA method applying IBL antibodies (RE-54031, Immunological Laboratories). The results showed that 24-hour urinary 6-HMS excretion in the studied premenopausal women were as follows: group Ia – 15.13±5.83 µg/24 h, group II – 28.85±12.59 µg/24 h (p<0,01), group III – 26.10±11.76 µg/24 h (p<0,01) and in the postmenopausal subjects they were: group Ib – 10.66±3.23 µg/24 h, group IV – 13.73±5.09 µg/24 h ((p=0,02), group V – 21.39±10.88 µg/24 h (p<0,01). In women with IBS-C the obtained results of 24-hour 6-HMS urinary excretion were independent on the intensity of clinical symptoms. On the other hand, in women with IBS-D, both in the group III and V, higher intensity of ailments was accompanied by significantly increased 6-HMS urinary excretion. The results of the study allowed drawing the following conclusions: (1). 24-hour 6-HMS urinary excretion in women with the constipation-predominant (IBS-C) as well as the diarrhoea-predominant IBS (IBS-D) is higher than in healthy persons both in the premenopausal and postmenopausal period. (2). Relatively high 6-HMS urinary excretion in postmenopausal women with IBS-D indicates an adaptive increase in MT secretion from EC in the gut.

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Association between estrogen receptor alpha gene polymorphisms and bone mineral density in Polish female patients with Graves' disease

80%

Ignaszak-Szczepaniak M., Horst-Sikorska W., Dytfeld J., Gowin E., Slomski R., Stajgis M.

Acta Biochimica Polonica

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2011

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tom 58

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nr 1

Graves' (GD) hyperthyroidism leads to reduced bone mineral density (BMD) accompanied by accelerated bone turnover. Ample studies have identified association between estrogen receptor (ESR1) gene polymorphism and decreased BMD and osteoporosis. In contrast, number of publications that link ESR1, BMD and Graves' disease is limited. The purpose of this study was to identify the association between ESR1 polymorphisms and BMD in premenopausal women with GD and to determine whether ESR1 polymorphic variants can predispose to GD. The study included 75 women aged 23-46 years with GD and 163 healthy controls. BMD was measured at lumbar spine and femoral neck. We investigated two SNPs in the ESR1 gene and analyzed genetic variants in the form of haplotypes reconstructed by statistical method. Three out of four possible haplotypes of the PvuII and XbaI restriction fragment length polymorphisms were found in GD patients: px (55.3 %), PX (33.3 %) and Px (11.4 %). Women homozygous for xx of XbaI and for pp of PvuII had the lowest BMD at lumbar spine. Moreover, the px haplotype predisposed to reduced lumbar BMD. No associations were observed for femoral neck BMD. No statistically significant relationship were found between ESR1 polymorphisms or their haplotypes and GD. These results indicate that the PvuII and the XbaI polymorphisms of ESR1 gene are associated with bone mineral density in premenopausal women with GD and may help to estimate the risk of bone loss particularly at lumbar spine. However, none of the ESR1 gene alleles predict the risk of GD in Polish female patients.

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Monitoring obesity during dietary therapies using hypocaloric diet and vegetable soup supplement

80%

Tapozada S. T., El-Shebini S. M., Hanna L. M., Mohamed H. I., Ghattas L. A.

Polish Journal of Food and Nutrition Sciences

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2007

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tom 57

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nr 3

381-385

This study was aimed at determining the effects of a radish-root-based mixed dried vegetable soup supplement as an adjunct to a balanced hypocaloric diet therapy in the management of obesity. Sixteen healthy obese middle aged women, divided into two equal groups, followed a hypocaloric (1000 Kcal/day) diet for four weeks. The first group consumed an additional portion of the soup twice daily, i.e. before lunch and before dinner. The second group served as control. Relevant anthropometric and biochemical parameters were measured before, after two and after four weeks. Both, the soup and control dieters lost 4.18% and 4.71% of their weights, respectively. The soup dieters showed a significant decrease in blood pressure and triglycerides. Total cholesterol levels showed slight variations in both groups. LDL-Cholesterol was significantly decreased in the control dieters, whereas superoxide dismutase (SOD) was significantly increased in the soup, but not in the control dieters. The negligible increase in the c-reactive protein (CRP) in the soup dieters contrasted with the highly significant rise of the control. Calcium was decreased to subnormal concentrations in both groups, while copper, zinc and magnesium showed variable but beneficial increases. We emphasize during and post-diet monitoring of serum TG, CRP and calcium for a more efficient obesity control. Regular consumption of the soup by virtue of its antioxidant and anti-inflammatory properties will help to blunt and/or delay weight cycling and other complications of obesity.

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The effects of male gender and female sex hormone deficiency on the vascular responses of the rat in vitro

70%

Nevala R., Paakkari I., Tarkkila L., Vapaatalo H.

Journal of Physiology and Pharmacology

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1996

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tom 47

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nr 3

Ograniczanie wyników

Expression of estrogen receptors in the pelvic floor of pre- and post-menopausal women presenting pelvic organ prolapse

Evaluation of urinary 6-hydroxymelatonin sulphate excretion in women at different age with irritable bowel syndrome

Association between estrogen receptor alpha gene polymorphisms and bone mineral density in Polish female patients with Graves' disease

Monitoring obesity during dietary therapies using hypocaloric diet and vegetable soup supplement

The effects of male gender and female sex hormone deficiency on the vascular responses of the rat in vitro