Wyniki wyszukiwania

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Worsening of long-term myocardial function after successful pharmacological pretreatment with cyclosporine

100%

Laudi S., Weimann J., Haschke M., Trump S., Schmitz V., Christians U., Kaisers U., Steudel W.

Journal of Physiology and Pharmacology

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2007

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tom 58

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nr 1

Pretreatment with cyclosporine (CsA) decreases infarct size 24h after myocardial ischemia/reperfusion (I/R). The goal of this study was to determine effects of CsA pretreatment on long-term cardiac function after I/R-injury. Rats were randomly assigned to group1: vehicle-only, group2: CsA-5mg/kg/day, and group3: CsA-12.5mg/kg/day given orally for three days prior to I/R-injury (30 min of left anterior descending coronary artery occlusion). Post-I/R survival and cardiac function were evaluated 14 days after I/R-injury by echocardiography and invasive hemodynamic measurements. Rats with I/R-injury showed increased left ventricular pressure (LVEDP) compared to rats without I/R-injury (p<0.005). Although CsA initially decreased infarct size, no differences of LVEDP were seen 14 days after I/R-injury (vehicle: 21.2±8.9 mmHg, CsA-5mg/kg/day: 21.5±0.7 mmHg, CsA-12.5mg/kg/day: 20.5±9.4 mmHg). Ejection fraction and fractional shortening were decreased compared to baseline, but showed no differences between groups. On day 14, a dose-dependent increase in left ventricular end diastolic diameter was seen (p<0.001). CsA pretreatment was associated with a dose-dependent decrease in post-I/R-survival (vehicle: 56%, CsA-5mg/kg/day: 32%, CsA-12.5mg/kg/day: 16%; p=0.017). CsA pretreatment did not improve long-term cardiac function despite decreased infarct size 24h after I/R-injury, but increased post-I/R mortality significantly. Poor cardiac function after CsA pretreatment might be caused by left ventricular dilation.

2

The role of adenosine in preconditioning

86%

De Jong J. W., De Jonge R., Bradamante S.

Cellular and Molecular Biology Letters

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1999

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tom 04

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nr 3

3

The influence of long-term ischemia and short-term ischemia-reperfusion on enzyme responses in rabbit blood

72%

Grabowska M., Drozdz W., Schlegel-Zawadzka M.

Acta Biologica Cracoviensia. Series Zoologia

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2004

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tom 46

4

Brain preconditioning and obstructive sleep apnea syndrome

72%

Brzecka A.

Acta Neurobiologiae Experimentalis

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2005

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tom 65

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nr 2

5

The platelet activating factor triggers preconditioning-like cardioprotective effect via mitochondrial K-ATP channels and redox-sensible signaling

72%

Penna C., Mognetti B., Tullio F., Gattullo D., Mancardi D., Pagliaro P., Alloatti G.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 1

Endogenous platelet activating factor (PAF) is involved in heart ischemic preconditioning. PAF can also afford pharmacological preconditioning. We studied whether mitochondrial-ATP-sensitive K+ (mKATP) channels and reactive oxygen species (ROS) are involved in PAF-induced cardioprotection. In Group 1 control hearts, Langendorff-perfused rat hearts underwent 30 min ischemia and 2 hours of reperfusion. Group 2 hearts, before ischemia, were perfused for 19 min with PAF (2x10-11 M); Groups 3 and 4 hearts were co-infused with PAF and N-acetyl-L-cysteine or 5-hydroxydecanoate to scavenge ROS or to block mKATP channels, respectively. Left ventricular pressure and infarct size were determined. PAF-pretreatment reduced infarct size (33 ± 4% vs 64 ± 4.6 % of the area at risk of control hearts) and improved pressure recovery. Infarct-sparing effect of PAF was abolished by N-acetyl-L-cysteine and 5-hydroxydecanoate. Thus, the cardioprotective effect exerted by PAF-pretreatment involves activation of mKATP channels and redox signaling in pre-ischemic phase.

6

Does preconditioning protect against experimental ischaemia-reperfusion injury via cholinergic stimulation?

72%

Dzierzkowska J., Gajewska J., Witanowska A., Deptuch T. W., Kurenko M., Gajewski M., Mautiris J., Kuzma M., Dron T., Maslinski S.

Journal of Physiology and Pharmacology. Supplement

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1997

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tom 48

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nr 2

7

Effects of environmental preconditioning, donor tissue and isolation conditions on tomato [Lycopersicon esculentum Mill.] protoplast yield

58%

Kuzniak E., Wielanek M., Malolepsza U., Urbanek H.

Acta Agrobotanica

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1995

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tom 48

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nr 2

113-120

The effects of soil or in vitro grown plants, pretreatment conditions, donor tissue and isolation procedure on protoplast yield from cotyledons and leaves of tomato cv. 'Perkoz' and 'Zorza' were studied. The highest protoplast yield of 1.5 x l0(7) /g FW was obtained from leaves of in vitro grown plants. Low light intensity during donor plants in vitro culture and dark pretreatment were essential for successful protoplast isolation while cold pretreatment was not. Tissue preplasmolysis prior to transfer to enzyme mixture increased 4-fold the number of isolated protoplasts. Glycine and bovine serum albumin in the isolation medium did not significantly influence the protoplast yield.

8

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The effect of selected biostimulants on seed germination of four plant species

51%

Acta Agrophysica

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2017

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tom 24

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nr 4

A laboratory experiment was conducted in 2015 to evaluate the germination energy and capacity of seeds of four ornamental plant species, treated with various biologically active substances. Three replications of the experiment were performed in three independent series. The experimental materials comprised seeds of four ornamental plant species: China aster (Callistephus chinensis (L.) Nees), scarlet sage (Salvia splendens Sellow ex Roemer & J.A. Schultes), common zinnia (Zinnia elegans Jacq.) and French marigold (Tagetes patula L.), which constituted the first experimental factor. The second experimental factor were biostimulants used for seed pre-conditioning: Effective Microorganisms, Trichoderma spp. and Goёmar Goteo. Seeds soaked in distilled water were the control. French marigold seeds were characterised by the highest average germination energy and capacity in three experimental series (mean values) and in each of the series. Scarlet sage seeds had the lowest germination energy, and common zinnia seeds had the lowest germination capacity in experimental series 1 and 3 and in three series (mean values). The biostimulants used for pre-conditioning exerted varied effects on the germination energy and capacity of seeds of the analysed ornamental plant species. The plant species compared in the study responded differently to the tested biostimulants. The germination energy and capacity of seeds of Callistephus chinensis (L.) Ness and Tagates patula L. decreased in response to the applied biostimulants.

Ograniczanie wyników

Worsening of long-term myocardial function after successful pharmacological pretreatment with cyclosporine

The role of adenosine in preconditioning

The influence of long-term ischemia and short-term ischemia-reperfusion on enzyme responses in rabbit blood

Brain preconditioning and obstructive sleep apnea syndrome

The platelet activating factor triggers preconditioning-like cardioprotective effect via mitochondrial K-ATP channels and redox-sensible signaling

Does preconditioning protect against experimental ischaemia-reperfusion injury via cholinergic stimulation?

Effects of environmental preconditioning, donor tissue and isolation conditions on tomato [Lycopersicon esculentum Mill.] protoplast yield

The effect of selected biostimulants on seed germination of four plant species