Wyniki wyszukiwania

1

The NHE3 inhibitor AVE1599 stimulates phrenic nerve activity in the rat

100%

Wiemann M., Piechatzek L., Gopelt K., Kiwull-Schone H., Kiwull P., Bingmann D.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 1

The effect of AVE1599, an inhibitor of the sodium/proton exchanger type 3 (NHE3), on phrenic nerve (PN) activity was investigated using the working heart brainstem preparation (WHBP). Hypercapnia (pH: -0.1) applied for 10 min reversibly increased PN frequency (f) by 66.0 ± 19.5% and decreased burst duration by 23.3 ± 3% (mean ± SE, n = 21). Similarly, AVE1599 (0.3µM) increased f after 10 and 30 min by 75.1 ± 13.2 and 176 ± 36.2% (n = 10), respectively, and reduced duration of PN bursts by 24.9 ± 10.8%. Hypercapnia-induced increases of f were attenuated by AVE1599. An elevated concentration of AVE1599 (0.9µM) had no significant effect on PN. As AVE1599 accumulates in brain tissue and might interfere with the less affine NHE1, we furthermore tested the NHE1-inhibitor HOE642. In fact, HOE642 (0.9µM) diminished f by 88.5 ± 9.2 and 58.6 ± 10.0% after 10 and 30 min (n = 6), respectively, but did not abolish hypercapnic responses. We conclude that AVE1599 augments central respiratory drive in the WHBP via NHE3 but not NHE1 inhibition.

2

Phrenic nerve activity is enhanced by 5-HT1A receptor agonist 8-OH-DPAT in spontaneously breathing anesthetized rats

86%

Valic M., Pecotic R., Dogas Z.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 1

Activation of serotonin 1A (5-HT1A) receptors has been shown to have diverse effects on respiration. The purpose of this study was to determine changes in respiratory motor pattern of phrenic nerve activity and respiratory rhythm after systemic application of specific 5-HT1A receptor agonist 8-hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT). We hypothesized that systemic application of specific 5-HT1A receptor agonist 8-OH-DPAT in spontaneously breathing anaesthetized rats will enhance phrenic motor output and phrenic respiratory rate. The study was performed in spontaneously breathing urethane anesthetized rats. Intravenous application of 8-OH-DPAT produced dose dependent increase in the amplitude of integrated phrenic nerve activity and disturbances in respiratory rhythm. Stimulating effect of 8-OH-DPAT on phrenic nerve activity was abolished by intravenous application of the selective 5-HT1A receptor antagonist WAY, N-(2-(4,2-methoxyphenyl)-1-piperazinyl)ethyl)-N-2-pyridinyl-cyclohexane-carboxamide maleate (WAY-100635). These results show that stimulation of 5-HT1A receptors by intravenous application of 8-OH-DPAT enhances phrenic nerve activity in spontaneously breathing rats.

3

Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia

72%

Ivancev B., Carev M., Pecotic R., Valic M., Pavlinac Dodig I., Karanovic N., Dogas Z.

Journal of Physiology and Pharmacology

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2013

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tom 64

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nr 4

4

Changes in short-term potentiation of hypoglossal activity by modulators of nitric oxide production in the rabbit

72%

Budzinska K., Wojtal E.

Acta Neurobiologiae Experimentalis

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2001

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tom 61

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nr 4

Ograniczanie wyników

3 Journal of Physiology and Pharmacology

1 Acta Neurobiologiae Experimentalis

2 Dogas Z.

2 Pecotic R.

2 Valic M.

1 Bingmann D.

1 Budzinska K.

1 Carev M.

1 Gopelt K.

1 Ivancev B.

1 Karanovic N.

1 Kiwull P.

1 Kiwull-Schone H.

1 Pavlinac Dodig I.

1 Piechatzek L.

1 Wiemann M.

1 Wojtal E.

1 2013

2 2008

1 2001

The NHE3 inhibitor AVE1599 stimulates phrenic nerve activity in the rat

Phrenic nerve activity is enhanced by 5-HT1A receptor agonist 8-OH-DPAT in spontaneously breathing anesthetized rats

Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia

Changes in short-term potentiation of hypoglossal activity by modulators of nitric oxide production in the rabbit