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Comparison of the serum level and pharmacokinetic parameters of oxytetracycline after administration of long action preparations in sheep

100%

Neuschl J., Popelka P., Nagy J., Sokol J., Marcincak S.

Medycyna Weterynaryjna

2007

tom 63

nr 03

294-297

Blood serum concentrations and biological half-life of oxytetracycline (OTC) after long action preparations were investigated in adult sheep of the Slovak Merino breed. A the same time their local tolerance has also been observed. In the first group oxytetracycline was administered in the form of preparation Tetraxyl L. A. inj. a.u.v. and in the second group in the form of preparations Alamycin L.A. inj. a.u.v. The blood serum concentrations of OTC were studied at intervals of 1, 3, 6, 24 hours and 2, 3, 4 and 5 days after single administration of the preparations. Oxytetracycline has been determined by high HPLC chromatography. Therapeutically concentrations of OTC (above 0.5 ?g.ml-1) produced by Tetraxyl were detected within 74 hours and after Alamycin administration within 67?68 hours. Detectable concentrations of OTC (under MIC) of Tetraxyl (0.28 ?g.ml-1) and Alamycin (0.14 ?g.ml-1) were recorded in 96 hours. On the 5th day all samples in both groups were negative. Biological half-life of Tetraxyl was determined at 36.5?38.5 hours and Alamycin at 36.0?37.0 hours. Short-time palpation hyperaesthesia was recorded in 1 sheep (within 13 hours) after Tetraxyl administration and in 2 sheep (within 15 hours) from the Alamycin group. On the basis of the results it was concluded that in selected pharmaceutically parameters and also in local tolerance Tetraxyl L.A. is more favorable in comparison with Alamycin L.A.

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Nucleotide analogue, method of synthesis of nucleotide analogue, use of nucleotide analogue, antiviral pro-nucleotide, pharmaceutical composition

100%

Kraszewski A., Romanowska J., Szymanska-Michalak A., Sobkowski M., Boryski J., Stawinski J., Lipniacki A., Piasek A.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

2014

tom 95

nr 4

Ograniczanie wyników

1 BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

1 Medycyna Weterynaryjna

1 Boryski J.

1 Kraszewski A.

1 Lipniacki A.

1 Marcincak S.

1 Nagy J.

1 Neuschl J.

1 Piasek A.

1 Popelka P.

1 Romanowska J.

1 Sobkowski M.

1 Sokol J.

1 Stawinski J.

1 Szymanska-Michalak A.

1 2014

1 2007

Wyniki wyszukiwania

Comparison of the serum level and pharmacokinetic parameters of oxytetracycline after administration of long action preparations in sheep

Nucleotide analogue, method of synthesis of nucleotide analogue, use of nucleotide analogue, antiviral pro-nucleotide, pharmaceutical composition