Wyniki wyszukiwania

1

DOI, an agonist of 5-HT2A-2C serotonin receptor, alters the expression of cyclooxygenase-2 in the rat parietal cortex

100%

Mackowiak M., Chocyk A., Sanak M., Czyrak A., Fijal K., Wedzony K.

Journal of Physiology and Pharmacology

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2002

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tom 53

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nr 3

The hallucinogenic effect of DOI, serotonin 5-HT2A/2C receptor agonist, is known to be associated with the activation of cortical 5-HT2 receptors. However, the effect of DOI on excitability of cortical neurons and their subsequent function is still not quite understood. Previous immunohistochemical studies using Fos proteins expression as a marker of neuronal activity showed the involvement of arachidonic acid cascade, particularly cyclooxygenase metabolic pathway, in DOI-induced Fos proteins expression in the rat parietal cortex. DOI increases arachidonic acid release which is transformed itself via acceleration of cyclooxygenase metabolic pathway to biologically active metabolites, such as prostaglandins and tromboxanes. Since cyclooxygenase-2 (COX-2) expression correlates with neuronal activity, it was of interest to investigate whether DOI is capable of influencing the level of COX-2 protein and mRNA expression in the rat parietal cortex. It was observed that neurons which were positive for 5-HT2A receptors showed constitutive COX-2 immunoreactivity. It was found further, that COX-2 protein level was increased at 1h, and returned to the control level at 3 and 6 h after DOI (5 mg/kg) administration. In contrast, DOI decreased the COX-2 mRNA expression at all tested time points (1h, 3h and 6h after DOI treatment). The obtained results further support the suggestion that COX-2 activation and possibly arachidonic acid metabolites generated by COX-2 may be considered as important mediators of functional responses generated by activation of cortical 5-HT2A/2C receptors.

2

Visual and auditory attentional capture are both sluggish in children with developmental dyslexia

100%

Facoetti A., Lorusso M. L., Cattaneo C., Galli R., Molteni M.

Acta Neurobiologiae Experimentalis

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2005

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tom 65

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nr 1

3

Contralateral somatosensory neglect in unrestrained rats after lesion of the parietal cortex of the left hemisphere

80%

Holm S., Mogensen J.

Acta Neurobiologiae Experimentalis

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1993

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tom 53

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nr 4

4

Retention and relearning of spatial delayed alternation in rats after combined or sequential lesions of the prefrontal and parietal cortex

80%

Wortwein G., Mogensen J., Divac I.

Acta Neurobiologiae Experimentalis

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1993

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tom 53

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nr 2

Ograniczanie wyników

3 Acta Neurobiologiae Experimentalis

1 Journal of Physiology and Pharmacology

2 Mogensen J.

1 Cattaneo C.

1 Chocyk A.

1 Czyrak A.

1 Divac I.

1 Facoetti A.

1 Fijal K.

1 Galli R.

1 Holm S.

1 Lorusso M. L.

1 Mackowiak M.

1 Molteni M.

1 Sanak M.

1 Wedzony K.

1 Wortwein G.

1 2005

1 2002

2 1993

DOI, an agonist of 5-HT2A-2C serotonin receptor, alters the expression of cyclooxygenase-2 in the rat parietal cortex

Visual and auditory attentional capture are both sluggish in children with developmental dyslexia

Contralateral somatosensory neglect in unrestrained rats after lesion of the parietal cortex of the left hemisphere

Retention and relearning of spatial delayed alternation in rats after combined or sequential lesions of the prefrontal and parietal cortex