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1

Boric acid as a protector against paclitaxel genotoxicity

100%

Turkez H., Tatar A., Hacimuftuoglu A., Ozdemir E.

Acta Biochimica Polonica

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2010

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tom 57

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nr 1

95-97

Paclitaxel (PAC) is an anticancer drug used for treatments of breast, ovarian and lung cancers. However, little data is; available in the literature on its potential genotoxicity on healthy human cells. On the other hand, boron deficiency and supplementation exert important biological effects in human and animal tissues. The biological effects of dietary boron are defined, but its interaction with PAC is not known for therapeutic uses. The aim of the present study was to determine whether boric acid (BA) confer a protection against PAC genotoxicity. After the application of PAC (10 or 20 μg/l) and BA (2.5 or 5 mg/l), the genotoxic effects were assessed by sister chromatid exchange (SCE) and micronucleus (MN) tests in human blood cultures. We also analyzed nuclear division index (NDI) in peripheral lymphocytes. Our results showed that PAC significantly (P < 0.05) increased the frequencies of SCEs and the formations of MNs in peripheral lymphocytes as compared to controls. PAC decreased the nuclear division index in lymphocyte cultures. Boric acid did not show cytotoxic or genotoxic effects at the concentrations tested. Furthermore, the PAC-induced increases in the genotoxicity and cytotoxicity indices were diminished by the addition of BA. The present study suggests for the first time that BA can prevent the genotoxicity of PAC on human lymphocytes.

2

Paclitaxel and cephalomannine in in vitro cultures of Taxus cuspidata Sieb. et Zucc. shoots and plantlets

80%

Oledzka H., Gajdzis-Kulis D., Gaska A., Stefanska K., Bogdanowicz A., Mistrzak P., Olszowska O.

Herba Polonica

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2009

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tom 55

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nr 3

231-237

Micropropagation of a mature female Taxus cuspidata tree with paclitaxel and cephalomannine content in the needles of 457.6 μg g-1 DW and 340.9 μg g-1 DW, respectively, was elaborated using shoot tips as explants. A new yew clone derived from a seed of the mother plant was also obtained. Single shoots developed from shoot tips on WP mineral basal medium with B5 vitamins (WP-B5) supplemented with 20 mg l-1 BAP and 5 mg l-1 activated charcoal were propagated by 1 cm long segments cultured on hormone-free medium. When WP-B5 medium with 0.3 mg/l 2-iP and 0,1 mg/l IAA was used 92% of shoots rooted within three months. Paclitaxel content in shoots growing on solid medium and in a mist trickling bioreactor was 45.6–86.5 μg g-1 DW. Plantlets from in vitro culture, grown in pots contained 99.0–213.1 μg g-1 paclitaxel and 558.0 μg g-1 DW cephalomannine.

3

The effect of the nitroxide pirolin on oxidative stress induced by doxorubicin and taxanes in the rat brain

80%

Tabaczar S., Czepas J., Koceva-Chyla A., Kilanczyk E., Piasecka-Zelga J., Gwozdzinski K.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 2

4

Influence of extract from shoots of Taxus baccata var.elegantissima on ultrastructure and tubulin cytoskeleton of meristematic cells of Allium cepa L. roots

80%

Majewska A., Furmanowa M., Glowniak K., Guzewska J., Zobel A., Kuras M.

Acta Societatis Botanicorum Poloniae

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2002

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tom 71

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nr 3

5

Effect of water extracts from needle surface of Taxus baccata and T. baccata var. elegantissima of life-history parameters of two-spotted spider mite [Tetranychus urticae Koch.]

80%

Furmanowa M., Kropczynska D., Zobel A., Glowniak K., Sahajdak A., Guzewska J., Jozefczak A., Rapczewska L.

Herba Polonica

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2001

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tom 47

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